5-Benzyl-1,2,4-triazol-3-carboxamid | 63970-80-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Benzyl-1,2,4-triazol-3-carboxamid
• 英文别名: 5-benzyl-1H-[1,2,4]triazole-3-carboxylic acid amide
• CAS: 63970-80-9
• 化学式: C₁₀H₁₀N₄O
• 分子量: 202.216
• InChiKey: SPJVJWMKIYGZLD-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  5-Benzyl-1,2,4-triazol-3-carboxamid 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以75%的产率得到benzyl-3(5)carboxyhydrazino-5(3)triazole-1,2,4
  参考文献：
  名称：

  合成s-triazolo [4,3-d]等[1,5-d]三嗪-1,2,4

  摘要：

  从5-（3）-烷基-开始获得2-取代的s-三唑并[1，5-d]和3-取代的s-三唑并[4，3-d] -1,2-4-三嗪8-一。 3（5）-羧基肼基-1,2,4三唑和原甲酸乙酯。但是，在5（3）-β-D-呋喃呋喃糖基-3（5）-羧基肼基-1,2,4三唑的情况下，发现相同的反应不是有效的反应。

  DOI：

  10.1016/0040-4020(81)85033-8

文献信息

• [EN] HETEROCYCLIC AMIDES AS KINASE INHIBITORS<br/>[FR] AMIDES HÉTÉROCYCLIQUES À UTILISER EN TANT QU'INHIBITEURS DE KINASE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2014125444A1

  公开（公告）日：2014-08-21

  Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

  揭示了具有式（I）的化合物，其中X、Y、Z1、Z2、Z3、Z4、R5、RA、m、A、L和B如本文所定义，并公开了制备和使用这些化合物的方法。
• [EN] HETEROCYCLIC AMIDES AS KINASE INHIBITORS<br/>[FR] AMIDES HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE KINASE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2017109724A1

  公开（公告）日：2017-06-29

  Disclosed are compounds having the formula (I) wherein Q, X, A, L, B, Q4, R, RA, R5, n and m are as defined herein, and methods of making and using the same.

  揭示了具有式(I)的化合物，其中Q、X、A、L、B、Q4、R、RA、R5、n和m如本文所定义，并且揭示了制备和使用这些化合物的方法。
• Novel heterocyclic NF-kB inhibitors
  申请人：Leban Johann

  公开号：US20060069102A1

  公开（公告）日：2006-03-30

  The present invention relates to compounds of the general formula (1) and salts and physiologically functional derivatives thereof, wherein R 1 is independently hydrogen; alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; R 2 is independently —NR 3 R 4 , R 3 is independently alkyl, cycloalkyl, alkoxy, alkylamine, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, R 4 is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R 5 is independently H, COR 6 , CO 2 R 6 , SOR 6 , SO 3 R 6 , alkyl, cycloalkyl, alkoxy, —NH 2 , alkylamine, —NR 7 COR 6 , halogen, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R 6 is independently H, alkyl, cycloalkyl, —NH 2 , alkylamine, aryl or heteroaryl; R 7 is independently H, alkyl, cycloalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or 1; q is 0, or 1; X is CO, or SO 2 .

  本发明涉及一般式（1）的化合物及其盐和生理功能衍生物，其中R1独立地为氢；烷基，环烷基，羟基烷基，卤代烷基，卤代烷氧基，芳基，取代芳基，杂芳基，取代杂芳基，芳基烷基或取代芳基烷基；R2独立地为—NR3R4，R3独立地为烷基，环烷基，烷氧基，烷基胺，—OH，—SH，烷硫基，羟基烷基，卤代烷基，卤代烷氧基，芳基或杂芳基，R4独立地为烷基，环烷基，烷氧基，烷基胺，烷硫基，羟基烷基，卤代烷基，卤代烷氧基，芳基或杂芳基；R5独立地为H，COR6，CO2R6，SOR6，SO3R6，烷基，环烷基，烷氧基，—NH2，烷基胺，—NR7COR6，卤素，—OH，—SH，烷硫基，羟基烷基，卤代烷基，卤代烷氧基，芳基或杂芳基；R6独立地为H，烷基，环烷基，—NH2，烷基胺，芳基或杂芳基；R7独立地为H，烷基，环烷基，烷氧基，—OH，—SH，烷硫基，羟基烷基，芳基或杂芳基；p为0或1；q为0或1；X为CO或SO2。
• Novel Heterocyclic Nf-Kb Inhibitors
  申请人：Leban Johann

  公开号：US20080261971A1

  公开（公告）日：2008-10-23

  The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, (I) wherein R 1 is independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; R 2 is independently —NR 3 R 4 , (II) or (III) R 3 is independently alkyl, cycloalkyl, alkoxy, alkylamine, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, R 4 is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R 5 is independently H, COR 6 , CO 2 R 6 , SOR 6 , SO 2 R 6 , SO 3 R 6 , alkyl, cycloalkyl, alkoxy, —NH 2 , alkylamine, —NR 7 COR 6 , halogen, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R 6 is independently H, alkyl, cycloalkyl, —NH 2 , alkylamine, aryl or heteroaryl; R 7 is independently H, alkyl, cycloalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or 1; q is 0, or 1; X is CO, or SO 2 .

  本发明涉及一般式(I)的化合物及其盐和生理功能衍生物，其中R1独立地为氢、烷基、环烷基、羟基烷基、卤代烷基、卤代烷氧基、芳基、取代芳基、杂环芳基、取代杂环芳基、芳基烷基或取代芳基烷基；R2独立地为—NR3R4、(II)或(III)，其中R3独立地为烷基、环烷基、烷氧基、烷基胺、—OH、—SH、烷硫基、羟基烷基、卤代烷基、卤代烷氧基、芳基或杂环芳基，R4独立地为烷基、环烷基、烷氧基、烷基胺、烷硫基、羟基烷基、卤代烷基、卤代烷氧基、芳基或杂环芳基；R5独立地为H、COR6、CO2R6、SOR6、SO2R6、SO3R6、烷基、环烷基、烷氧基、—NH2、烷基胺、—NR7COR6、卤素、—OH、—SH、烷硫基、羟基烷基、卤代烷基、卤代烷氧基、芳基或杂环芳基；R6独立地为H、烷基、环烷基、—NH2、烷基胺、芳基或杂环芳基；R7独立地为H、烷基、环烷基、烷氧基、—OH、—SH、烷硫基、羟基烷基、芳基或杂环芳基；p为0或1；q为0或1；X为CO或SO2。
• Novel Heterocyclic NF-kB Inhibitors
  申请人：LEBAN Johann

  公开号：US20100048583A1

  公开（公告）日：2010-02-25

  The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein R 1 is independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; R 2 is independently —NR 3 R 4 , R 3 is independently alkyl, cycloalkyl, alkoxy, alkylamine, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, R 4 is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R 5 is independently H, COR 6 , CO 2 R 6 , SOR 6 , SO 2 R 6 , SO 3 R 6 , alkyl, cycloalkyl, alkoxy, —NH 2 , alkylamine, —NR 7 COR 6 , halogen, —OH, —SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R 6 is independently H, alkyl, cycloalkyl, —NH 2 , alkylamine, aryl or heteroaryl; R 7 is independently H, alkyl, cycloalkyl, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or 1; q is 0, or 1; X is CO, or SO 2 .

  本发明涉及一般式(I)的化合物、盐和生理学功能衍生物，其中R1独立地为氢、烷基、环烷基、羟基烷基、卤代烷基、卤代烷氧基、芳基、取代芳基、杂芳基、取代杂芳基、芳基烷基或取代芳基烷基；R2独立地为—NR3R4，R3独立地为烷基、环烷基、烷氧基、烷基胺、—OH、—SH、烷基硫基、羟基烷基、卤代烷基、卤代烷氧基、芳基或杂芳基，R4独立地为烷基、环烷基、烷氧基、烷基胺、烷基硫基、羟基烷基、卤代烷基、卤代烷氧基、芳基或杂芳基；R5独立地为H、COR6、CO2R6、SOR6、SO2R6、SO3R6、烷基、环烷基、烷氧基、—NH2、烷基胺、—NR7COR6、卤素、—OH、—SH、烷基硫基、羟基烷基、卤代烷基、卤代烷氧基、芳基或杂芳基；R6独立地为H、烷基、环烷基、—NH2、烷基胺、芳基或杂芳基；R7独立地为H、烷基、环烷基、烷氧基、—OH、—SH、烷基硫基、羟基烷基、芳基或杂芳基；p为0或1；q为0或1；X为CO或SO2。