5-bromo-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole | 1227380-58-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-bromo-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole
• CAS: 1227380-58-6
• 化学式: C₁₇H₁₅BrN₂O₂
• 分子量: 359.222
• InChiKey: ZNZZVTJDSYJDBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-溴-2-甲基吲哚 、 β-硝基苯乙烯 以 水 为溶剂， 反应 0.1h， 以94%的产率得到5-bromo-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole
  参考文献：
  名称：

  A combination of water and microwave irradiation promotes the catalyst-free addition of pyrroles and indoles to nitroalkenes

  摘要：

  A combination of water and microwave irradiation was used for the first time to perform a catalyst-free nitro-Michael addition of pyrroles and indoles. Under superheated conditions, the water trends to ionize by changing its chemical and physical properties. Therefore, we performed a new green-protocol using the water either as environmentally no harm solvent or as catalyst. The reaction success is independent from the kind of pyrrole, indole or nitroalkenes rapidly affording the corresponding adducts and giving excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.055

文献信息

• A combination of water and microwave irradiation promotes the catalyst-free addition of pyrroles and indoles to nitroalkenes
  作者：Margherita De Rosa、Annunziata Soriente

  DOI：10.1016/j.tet.2010.02.055

  日期：2010.4

  A combination of water and microwave irradiation was used for the first time to perform a catalyst-free nitro-Michael addition of pyrroles and indoles. Under superheated conditions, the water trends to ionize by changing its chemical and physical properties. Therefore, we performed a new green-protocol using the water either as environmentally no harm solvent or as catalyst. The reaction success is independent from the kind of pyrrole, indole or nitroalkenes rapidly affording the corresponding adducts and giving excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.