4-(2-naphthyl)-2-(trifluoromethyl)-2,3-dihydro-1H-1,5-benzodiazepine | 1456805-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 4-(2-naphthyl)-2-(trifluoromethyl)-2,3-dihydro-1H-1,5-benzodiazepine
• CAS: 1456805-22-3
• 化学式: C₂₀H₁₅F₃N₂
• 分子量: 340.348
• InChiKey: JEVRIMLOUAYLBY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  4,4,4-trifluoro-1-(naphthalen-2-yl)but-2-en-1-one 、 邻苯二胺 以 二氯甲烷 为溶剂， 反应 24.0h， 以85%的产率得到4-(2-naphthyl)-2-(trifluoromethyl)-2,3-dihydro-1H-1,5-benzodiazepine
  参考文献：
  名称：

  Synthesis of trifluoromethylated 1,5-benzoheteroazepines

  摘要：

  Because of the great interest of benzoheteroazepines and trifluoromethylated compounds in medicinal chemistry, a simple strategy to synthesize trifluoromethylated 1,5-benzoheteroazepines have been described. Starting from beta-trifluoromethylated enones and 1,2-diamines or 1,2-thioamines, various benzodiazepines and benzothiazepines bearing a CF3 group have been obtained in good yields. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.06.016