4-(3-Ethenyl-4-propan-2-yloxyphenyl)pyridine | 1210502-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(3-Ethenyl-4-propan-2-yloxyphenyl)pyridine
• 英文别名: 4-(3-ethenyl-4-propan-2-yloxyphenyl)pyridine
• CAS: 1210502-13-8
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: JQVOMUVFLIPHAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-isopropoxy-5-(pyridin-4-yl)benzaldehyde 、 甲基三苯基溴化膦 在 lithium hexamethyldisilazane 作用下， 以 替加氟 为溶剂， 反应 12.0h， 以86%的产率得到4-(3-Ethenyl-4-propan-2-yloxyphenyl)pyridine
  参考文献：
  名称：

  Acid-mediated activation of modified ring-closing metathesis catalysts

  摘要：

  To improve the reactivity of Grubbs catalyst, novel ligands were designed and synthesized which possess nitrogen-containing heterocycles such as imidazole and pyridine. The modified catalysts were treated with a range of acids and the acid salt forms were used as catalysts for ring-closing metathesis (RCM) reactions. As a result, reactions employing the acid-modified catalysts showed considerable reactivity enhancement in RCM. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.112

文献信息

• Acid-mediated activation of modified ring-closing metathesis catalysts
  作者：Seyoung Kim、Wonmi Hwang、In Seon Lim、Sung Hye Kim、Sang-gi Lee、B. Moon Kim

  DOI：10.1016/j.tetlet.2009.11.112

  日期：2010.1

  To improve the reactivity of Grubbs catalyst, novel ligands were designed and synthesized which possess nitrogen-containing heterocycles such as imidazole and pyridine. The modified catalysts were treated with a range of acids and the acid salt forms were used as catalysts for ring-closing metathesis (RCM) reactions. As a result, reactions employing the acid-modified catalysts showed considerable reactivity enhancement in RCM. (C) 2009 Elsevier Ltd. All rights reserved.