[1-14C]tetradecanoate N-hydroxysuccinimide ester | 289034-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [1-14C]tetradecanoate N-hydroxysuccinimide ester
• 英文别名: [1-14C]tetradecanoate N-hydroxysuccinimid；(2,5-dioxopyrrolidin-1-yl) (114C)tetradecanoate
• CAS: 289034-57-7
• 化学式: C₁₈H₃₁NO₄
• 分子量: 327.437
• InChiKey: NZEDHZOVUDEBGW-GTFORLLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 [1-14c]-肉豆蔻油酸 在 N,N'-二环己基碳二亚胺 作用下， 以 丙酮 为溶剂， 反应 22.0h， 以95%的产率得到[1-14C]tetradecanoate N-hydroxysuccinimide ester
  参考文献：
  名称：

  [125I]- and [14C]-labelling of the long-acting insulin derivative NN304

  摘要：

  Lys(epsilon B29) Tetradecanoyl des(B30) human insulin, Novo Nordisk code no NN304, is a long-acting human insulin derivative that differs from human insulin by being more than 98% albumin bound in plasma. The syntheses of [I-125]Tyr(A14) N-epsilon-Lys(epsilon B29) Tetradecanoyl des(B30) human insulin ([I-125]NN304) and Lys(epsilon B29) [1-C-14]-Tetradecanoyl des(B30) human insulin ([C-14]NN304) used for absorption, distribution, metabolism and excretion (ADME) studies are described. NN304 was radio-iodinated using the lactopel oxidase/hydrogen peroxide method, and the product was isolated using RP-HPLC. Radio-peptide mapping confirmed the [I-125] labelling position at Tyrosine 14 in the A-chain. The radiochemical yield was 30% with a radiochemical purity of >98%. [C-14]-NN304 was synthesised in two steps starting from 1-[C-14] myristic acid and subsequently purified by HPLC. The overall radiochemical yield was 15% with a radiochemical purity >98%.

  DOI：

  10.1002/1099-1344(200006)43:7<671::aid-jlcr352>3.0.co;2-l

文献信息

• Kristensen, Jesper B.; Mueller, Lars K.; Larsen, Ulla D., Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 11, p. 1072 - 1072
  作者：Kristensen, Jesper B.、Mueller, Lars K.、Larsen, Ulla D.、Hansen, Louis B.、Foged, Christian

  DOI：——

  日期：——