2,2'-Dichlor-4,4'-di-tert-butylbiphenyl | 70728-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-Dichlor-4,4'-di-tert-butylbiphenyl
• 英文别名: 4-Tert-butyl-1-(4-tert-butyl-2-chlorophenyl)-2-chlorobenzene
• CAS: 70728-94-8
• 化学式: C₂₀H₂₄Cl₂
• 分子量: 335.317
• InChiKey: LNKILVJNFNIOGD-UHFFFAOYSA-N

物化性质

• 熔点：
  120-122 °C(Solv: ethanol (64-17-5))
• 沸点：
  358.8±37.0 °C(Predicted)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,2'-Dichlor-4,4'-di-tert-butylbiphenyl 在 三氯化铝 作用下， 以 苯 为溶剂， 生成 2,2'-二氯联苯
  参考文献：
  名称：

  Studies on selective preparation of aromatic compounds. 20. Selective preparation of 2-mono- and 2,2'-disubstituted biphenyl using the tert-butyl group as a positional protective group

  摘要：

  DOI：

  10.1021/jo01331a016
• 作为产物：
  描述：

  4,4'-二叔丁基苯并 在 氯 、 铁粉 作用下， 以 四氯化碳 为溶剂， 生成 2,2'-Dichlor-4,4'-di-tert-butylbiphenyl
  参考文献：
  名称：

  Studies on selective preparation of aromatic compounds. 20. Selective preparation of 2-mono- and 2,2'-disubstituted biphenyl using the tert-butyl group as a positional protective group

  摘要：

  DOI：

  10.1021/jo01331a016

文献信息

• A Highly Active and General Catalyst for the Stille Coupling Reaction of Unreactive Aryl, Heteroaryl, and Vinyl Chlorides under Mild Conditions
  作者：Dong-Hwan Lee、Yingjie Qian、Ji-Hoon Park、Jong-Suk Lee、Sang-Eun Shim、Myung-Jong Jin

  DOI：10.1002/adsc.201300075

  日期：2013.6.17

  efficient and general catalyst in the Stille coupling reaction of various aryl and heteroaryl chlorides with organostannanes. The results show that this catalytic system allows for the use of less reactive substrates such as deactivated or sterically hindered aryl chlorides. A catalyst loading of 0.5 mol% was sufficient to achieve excellent performance under relatively mild reaction conditions. Furthermore

  在各种芳基和杂芳基氯化物与有机锡的斯蒂尔偶联反应中，发现β-二酮亚氨基膦膦-钯配合物可作为一种有效的通用催化剂。结果表明，该催化体系允许使用反应性较低的底物，例如失活或空间受阻的芳基氯化物。0.5mol％的催化剂负载量足以在相对温和的反应条件下获得优异的性能。此外，催化剂的范围扩展到氯乙烯的偶联。
• Process for preparing carbazoles
  申请人：Dow Global Technologies LLC

  公开号：US10246415B2

  公开（公告）日：2019-04-02

  A process for preparing one or more carbazoles comprising (a) contacting one or more compounds represented by formula (1) below with diboron reagents in the presence of PdCl2(dppf) to form one or more 2,2′-dichlorobiaryl represented by formula (2) below; and (b) contacting the one or more 2,2′-dichlorobiaryls with one or more H2N—Y compounds, in the presence of one or more palladium containing catalytic components; thereby forming one or more carbazoles represented by formula (3) below is provided.

  一种制备一种或多种咔唑的工艺，包括(a)在PdCl2(dppf)存在下，将一种或多种下式(1)代表的化合物与二硼试剂接触，形成一种或多种下式(2)代表的2,2′-二氯叔丁基；和(b)在一种或多种含钯催化组分存在下，使一种或多种 2，2′-二氯芳基与一种或多种 H2N-Y 化合物接触，从而形成一种或多种如下式(3)所代表的咔唑。
• TASHIRO MASASHI; YAMATO TAKEHIKO, J. ORG. CHEM., 1979, 44, NO 17, 3037-3041
  作者：TASHIRO MASASHI、 YAMATO TAKEHIKO

  DOI：——

  日期：——
• [EN] PROCESS FOR PREPARING CARBAZOLES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CARBAZOLES
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2018013067A1

  公开（公告）日：2018-01-18

  A process for preparing one or more carbazoles comprising (a) contacting one or more compounds represented by formula (1) below with diboron reagents in the presence of PdCl2(dppf) to form one or more 2,2'-dichlorobiaryl represented by formula (2) below; and (b) contacting the one or more 2,2'-dichlorobiaryls with one or more H2N-Y compounds, in the presence of one or more palladium containing catalytic components; thereby forming one or more carbazoles represented by formula (3) below is provided.