N-[(E)-1-(2-methylphenyl)ethylidene]diphenyl-phosphinic amide | 1092577-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(E)-1-(2-methylphenyl)ethylidene]diphenyl-phosphinic amide
• CAS: 1092577-40-6
• 化学式: C₂₁H₂₀NOP
• 分子量: 333.37
• InChiKey: QONQPHSWIQYODP-RELWKKBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.73
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  29.43
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  三甲基氰硅烷 、 N-[(E)-1-(2-methylphenyl)ethylidene]diphenyl-phosphinic amide 在 zirconium(IV) tert-butoxide 、 (1S,8R,9S,1'S,8'R,9'S)-[8'-(hydroxy-diphenyl-methyl)-10,10,10',10'-tetramethyl-[5,5']bi[6-aza-tricyclo[7.1.1.0^2,7]undecyl]-2(7),3,5,2',4',6'-hexaen-8-yl]-diphenyl-methanol 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 生成 N-[1-cyano-1-(2-methylphenyl)ethyl]diphenyl-phosphinic amide 、 N-[1-cyano-1-(2-methylphenyl)ethyl]diphenyl-phosphinic amide
  参考文献：
  名称：

  Enantioselective Strecker-type reaction of phosphinoyl ketimines catalyzed by a chiral Zr-bipyridyldiol catalyst

  摘要：

  An enantioselective Strecker reaction of N-diphenylphosphinoyl ketimines with TMSCN employing a chiral zirconium complex formed from chiral bipyridyl diol 1 as catalyst is described. The catalytic efficiency of chiral ligand 1 with other Lewis acids was also explored. Higher yields (50-85%) with moderate to good enantioselectivities (30-80%) were achieved for a variety of N-diphenylphosphinoyl ketimines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.09.011
• 作为产物：
  描述：

  1-(o-tolyl)ethanone oxime 、 二苯基氯化膦 在 三乙胺 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 16.0h， 生成 N-[(E)-1-(2-methylphenyl)ethylidene]diphenyl-phosphinic amide
  参考文献：
  名称：

  Enantioselective Strecker-type reaction of phosphinoyl ketimines catalyzed by a chiral Zr-bipyridyldiol catalyst

  摘要：

  An enantioselective Strecker reaction of N-diphenylphosphinoyl ketimines with TMSCN employing a chiral zirconium complex formed from chiral bipyridyl diol 1 as catalyst is described. The catalytic efficiency of chiral ligand 1 with other Lewis acids was also explored. Higher yields (50-85%) with moderate to good enantioselectivities (30-80%) were achieved for a variety of N-diphenylphosphinoyl ketimines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.09.011