5-amino-3,4-dihydro-2H-pyrrole-2-carboxylic acid hydrochloride | 1461706-58-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylic acid hydrochloride
• 英文别名: 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylic acid;hydrochloride
• CAS: 1461706-58-0
• 化学式: C₅H₈N₂O₂*ClH
• mdl: MFCD25970427
• 分子量: 164.592
• InChiKey: QQOQGDXPWMKBGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.46
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  75.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氧代吡咯烷-2-羧酸乙酯 在 盐酸 、 氯化铵 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 32.0h， 生成 5-amino-3,4-dihydro-2H-pyrrole-2-carboxylic acid hydrochloride
  参考文献：
  名称：

  修改过的安德文霉素A的结构和安德文霉素生物合成基因簇的表征。

  摘要：

  安特万星A和B是委内瑞斯链霉菌ATCC 14583和14585产生的吡咯酰胺代谢产物。1965年分离，据报道它们具有驱虫和中度抗菌活性。在这项研究中，我们修改了蒽铁霉素A的结构，并鉴定了带有两个N-甲基化吡咯基团的第三蒽铁代谢物，我们将其命名为蒽铁霉素C。我们对委内瑞拉链球菌ATCC 14583的基因组进行了测序，并鉴定了预计可指导直接遗传的基因簇花粉生物素的生物合成。该基因簇的功能分析证实了它参与了蒽醌的生物合成，并允许我们提出蒽醌的生物合成途径。除非核糖体肽合成酶（NRPS）外，蒽醌素的组装还涉及来自ATP抓握连接酶家族的一种酶Ant23。我们建议Ant23使用负载PCP的4-氨基吡咯-2-羧酸盐作为底物。如观察到其他吡咯酰胺酰胺刚果（由Streptomyces ambofaciens ATCC 25877生产）和双歧霉素（由Streptomyces netropsis DSM 408

  DOI：

  10.1021/acschembio.9b00960

文献信息

• Inhibitors of hepatitis C virus NS3 protease
  申请人：——

  公开号：US20030064962A1

  公开（公告）日：2003-04-03

  The present invention relates generally to a novel class of pyrimidinones of Formula (I): 1 that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

  本发明一般涉及一种新型的嘧啶酮类化合物，具有如下式（I）所示的结构，这些化合物可用作丝氨酸蛋白酶抑制剂，更具体地作为丙型肝炎病毒NS3蛋白酶抑制剂。本发明还涉及包含这些化合物的药物组合物以及使用这些药物的方法。
• PRODUCTION OF POLYKETIDES
  申请人：Biotica Technology Limited

  公开号：EP1521828A2

  公开（公告）日：2005-04-13
• Production of polyketides and other natural products
  申请人：Biotica Technology Limited

  公开号：EP1589031B1

  公开（公告）日：2007-08-15
• PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS
  申请人：Gregory Alan Matthew

  公开号：US20080021211A1

  公开（公告）日：2008-01-24

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).
• Production of Polyketides and Other Natural Products
  申请人：Gregory Matthew Alan

  公开号：US20080287482A1

  公开（公告）日：2008-11-20

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).