(R)-4-[(2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-((2S,6R)-6-vinyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-yl]-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid | 884345-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-4-[(2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-((2S,6R)-6-vinyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-yl]-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid
• 英文别名: (3R)-4-[(2R,4S,6S)-6-[[(2S,6R)-6-ethenyloxan-2-yl]methyl]-6-methoxy-5,5-dimethyl-4-phenylmethoxyoxan-2-yl]-3-(2-trimethylsilylethoxymethoxy)butanoic acid
• CAS: 884345-60-2
• 化学式: C₃₃H₅₄O₈Si
• 分子量: 606.872
• InChiKey: RQHNNPMOXKCBIT-SHHHVCMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.81
• 重原子数：
  42
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (R)-4-[(2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-((2S,6R)-6-vinyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-yl]-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) N,N'-二环己基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  A preliminary evaluation of a metathesis approach to bryostatins

  摘要：

  Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at G 18, did not undergo the required ring-closing metathesis. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.097
• 作为产物：
  描述：

  2-(三甲基硅烷基)乙氧甲基氯 在 4-二甲氨基吡啶 、 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 、 四丁基氟化铵 、 戴斯-马丁氧化剂 、 N,N-二异丙基乙胺 作用下， 以 叔丁醇 为溶剂， 生成 (R)-4-[(2R,4S,6S)-4-Benzyloxy-6-methoxy-5,5-dimethyl-6-((2S,6R)-6-vinyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-yl]-3-(2-trimethylsilanyl-ethoxymethoxy)-butyric acid
  参考文献：
  名称：

  A preliminary evaluation of a metathesis approach to bryostatins

  摘要：

  Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at G 18, did not undergo the required ring-closing metathesis. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.097

文献信息

• A preliminary evaluation of a metathesis approach to bryostatins
  作者：Matthew Ball、Benjamin J. Bradshaw、Raphaël Dumeunier、Thomas J. Gregson、Somhairle MacCormick、Hiroki Omori、Eric J. Thomas

  DOI：10.1016/j.tetlet.2006.01.097

  日期：2006.3

  Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at G 18, did not undergo the required ring-closing metathesis. (c) 2006 Elsevier Ltd. All rights reserved.