4-(4-氟苯基)-2-甲基-6-[5-(1-哌啶基)戊氧基]嘧啶 | 259525-01-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4-(4-氟苯基)-2-甲基-6-[5-(1-哌啶基)戊氧基]嘧啶
• 中文别名: 2(1H)-喹喔啉酮,3,4-二氢-3,3,4-三甲基-
• 英文名称: 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine
• 英文别名: Enecadin；4-(4-fluorophenyl)-2-methyl-6-(5-piperidin-1-ylpentoxy)pyrimidine
• CAS: 259525-01-4
• 化学式: C₂₁H₂₈FN₃O
• 分子量: 357.471
• InChiKey: SZSHJTJCJOWMHM-UHFFFAOYSA-N

物化性质

• 沸点：
  487.7±40.0 °C(Predicted)
• 密度：
  1.099±0.06 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜：≥ 50 mg/mL（139.88 mM）

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  5

制备方法与用途

生物活性

Enecadin 是一种神经保护剂，来自专利 US 8623823 B2。

体外研究

Enecadin 可以用于治疗中风或其他脑血管意外，作为一种神经保护剂具有潜在的应用价值。

反应信息

• 作为产物：
  描述：

  哌啶戊醇 、 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine 以 环己烷 为溶剂， 生成 4-(4-氟苯基)-2-甲基-6-[5-(1-哌啶基)戊氧基]嘧啶
  参考文献：
  名称：

  PROCESS FOR PRODUCING PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF

  摘要：

  公开号：

  EP1318146B1

文献信息

• NOVEL PYRIMIDINE DERIVATIVE AND NOVEL PYRIDINE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1318147A1

  公开（公告）日：2003-06-11

  Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.

  非手性嘧啶衍生物和以下结构式或其类似物的吡啶衍生物具有选择性N型钙通道拮抗活性，并且当口服时表现出镇痛作用。它们可用作与N型钙通道相关的疼痛和各种疾病的治疗药物。
• Pyrimidine derivatives and new pyridine derivatives
  申请人：AJINOMOTO CO., INC.

  公开号：US20040009991A1

  公开（公告）日：2004-01-15

  Achirai pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels. 1

  Achirai嘧啶衍生物和以下结构式或其类似物的吡啶衍生物具有选择性N型钙通道拮抗活性，并在口服时显示镇痛作用。它们可用作与N型钙通道相关的疼痛和各种疾病的治疗药物。
• NEW PYRIMIDINE DERIVATIVES AND NEW PYRIDINE DERIVATIVES
  申请人：OHNO Seiji

  公开号：US20080070903A1

  公开（公告）日：2008-03-20

  Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.

  以下式子或其类似物的非手性嘧啶衍生物和吡啶衍生物具有选择性N型钙通道拮抗活性，并且口服时表现出镇痛作用。它们可用作治疗与N型钙通道相关的疼痛和各种疾病的治疗剂。
• Method for preventing or treating neurologic damage after spinal cord injury
  申请人：Kazui Teruhisa

  公开号：US20070021451A1

  公开（公告）日：2007-01-25

  The present invention provides a method for preventing and/or treating neurologic damage after spinal cord injury in a mammal including human in need thereof which comprises administering an effective amount of a compound of the general formula [I]: or a salt, or a solvate thereof, and a use thereof.

  本发明提供了一种预防和/或治疗哺乳动物，包括需要的人类，在脊髓损伤后神经损伤的方法，其包括给予一定量的一般式[I]的化合物或其盐、溶剂化物的有效量，以及其用途。
• NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION
  申请人：Barlow Carrolee

  公开号：US20070049576A1

  公开（公告）日：2007-03-01

  The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.

  该即时披露描述了通过刺激或增加神经发生来治疗中枢神经系统和外周神经系统的疾病和病症的方法。该披露包括基于毒蕈碱受体调节的组合物和方法，例如通过抑制乙酰胆碱酯酶（AChE）活性，单独或与另一种神经生成剂结合以刺激或激活新神经细胞的形成。