6-N-[6-[[6-[(6-bromopyridin-2-yl)amino]pyridin-2-yl]amino]pyridin-2-yl]pyridine-2,6-diamine | 794512-16-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-N-[6-[[6-[(6-bromopyridin-2-yl)amino]pyridin-2-yl]amino]pyridin-2-yl]pyridine-2,6-diamine
• CAS: 794512-16-6
• 化学式: C₂₀H₁₇BrN₈
• 分子量: 449.313
• InChiKey: NUUXLFDIJVIYNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-N-[6-[[6-[(6-bromopyridin-2-yl)amino]pyridin-2-yl]amino]pyridin-2-yl]pyridine-2,6-diamine 在 四(三苯基膦)钯 、 tris(dibenzylideneacetone)dipalladium (0) 、 1,3-双(二苯基膦)丙烷 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 sodium t-butanolate 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 6-[[6-[(6-imino-1H-pyridin-2-yl)imino]-1H-pyridin-2-yl]imino]-N-[6-[(6-pyridin-2-ylimino-1H-pyridin-2-yl)imino]-1H-pyridin-2-yl]-1H-pyridin-2-amine
  参考文献：
  名称：

  Synthesis of long-chained oligo-α-aminopyridines by tandem Pd-catalyzed cross-coupling aminations and their helical dinuclear complexes

  摘要：

  Three novel multidentate long-chained oligo-alpha-aminopyridine ligands, nonapyridyloctaamine (1, npoa), decapyridyinonaamine (2, dpna), and undecapyridyldecaamine (3, upda) were synthesized successfully by tandem Pd-catalyzed cross-coupling aminations. The helical structures of protonated ligand npoa {4, [H(4)npoa](SO3CF3)(4)} and the related dinuclear complexes 5-10 were synthesized and characterized by X-ray diffractions. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.08.066
• 作为产物：
  描述：

  N²-(6-bromopyridine-2-yl)pyridine-2,6-diamine 在 tris(dibenzylideneacetone)dipalladium (0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 sodium t-butanolate 作用下， 以 苯 为溶剂， 以80%的产率得到6-N-[6-[[6-[(6-bromopyridin-2-yl)amino]pyridin-2-yl]amino]pyridin-2-yl]pyridine-2,6-diamine
  参考文献：
  名称：

  Synthesis of long-chained oligo-α-aminopyridines by tandem Pd-catalyzed cross-coupling aminations and their helical dinuclear complexes

  摘要：

  Three novel multidentate long-chained oligo-alpha-aminopyridine ligands, nonapyridyloctaamine (1, npoa), decapyridyinonaamine (2, dpna), and undecapyridyldecaamine (3, upda) were synthesized successfully by tandem Pd-catalyzed cross-coupling aminations. The helical structures of protonated ligand npoa {4, [H(4)npoa](SO3CF3)(4)} and the related dinuclear complexes 5-10 were synthesized and characterized by X-ray diffractions. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.08.066

文献信息

• Synthesis of long-chained oligo-α-aminopyridines by tandem Pd-catalyzed cross-coupling aminations and their helical dinuclear complexes
  作者：Hasan Hasanov、Uan-Kang Tan、Rui-Ren Wang、Gene Hsiang Lee、Shie-Ming Peng

  DOI：10.1016/j.tetlet.2004.08.066

  日期：2004.10

  Three novel multidentate long-chained oligo-alpha-aminopyridine ligands, nonapyridyloctaamine (1, npoa), decapyridyinonaamine (2, dpna), and undecapyridyldecaamine (3, upda) were synthesized successfully by tandem Pd-catalyzed cross-coupling aminations. The helical structures of protonated ligand npoa 4, [H(4)npoa](SO3CF3)(4)} and the related dinuclear complexes 5-10 were synthesized and characterized by X-ray diffractions. (C) 2004 Elsevier Ltd. All rights reserved.