1-cyclopentyl-6-[(1R)-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | 1236861-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 1-cyclopentyl-6-[(1R)-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
• 英文别名: 1-cyclopentyl-6-[(1R)-1-(3-pyridin-4-ylpyrrolidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one
• CAS: 1236861-02-1
• 化学式: C₂₁H₂₆N₆O
• 分子量: 378.477
• InChiKey: KDKCYBNYZLSUIH-IURRXHLWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  75.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• AMINO-HETEROCYCLIC COMPOUNDS
  申请人：Claffey Michelle M.

  公开号：US20100190771A1

  公开（公告）日：2010-07-29

  The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , A, and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.

  这项发明提供了式（I）中的PDE9抑制化合物，以及其药学上可接受的盐，其中R1、R2、R3、A和n的定义如本文所述。还提供了含有式I中化合物的药物组合物，并且提供了在治疗神经退行性和认知障碍疾病，如阿尔茨海默病和精神分裂症中的用途。
• Amino-Heterocyclic Compounds
  申请人：Pfizer Inc.

  公开号：US20140088081A1

  公开（公告）日：2014-03-27

  The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , A, and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.

  本发明提供了PDE9抑制化合物的式(I)，及其药学上可接受的盐，其中R1，R2，R3，A和n的定义如本文所述。还提供了含有式(I)化合物的药物组合物，并将其用于治疗神经退行性和认知障碍，例如阿尔茨海默病和精神分裂症。
• Amino-heterocyclic compounds used as pde9 inhibitors
  申请人：Pfizer Inc.

  公开号：EP2389382A1

  公开（公告）日：2011-11-30
• US8278295B2
  申请人：——

  公开号：US8278295B2

  公开（公告）日：2012-10-02
• [EN] AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS<br/>[FR] COMPOSÉS AMINO-HÉTÉROCYCLIQUES EMPLOYÉS EN TANT QU'INHIBITEURS DE PDE9
  申请人：PFIZER

  公开号：WO2010084438A1

  公开（公告）日：2010-07-29

  The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, A1 and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.