2-bromomethyl-1,3-dichloro-5-trifluoromethylbenzene | 474889-71-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromomethyl-1,3-dichloro-5-trifluoromethylbenzene
• 英文别名: Benzene, 2-(bromomethyl)-1,3-dichloro-5-(trifluoromethyl)-；2-(bromomethyl)-1,3-dichloro-5-(trifluoromethyl)benzene
• CAS: 474889-71-9
• 化学式: C₈H₄BrCl₂F₃
• 分子量: 307.925
• InChiKey: RKEUOROPQMBYRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3,4,4-trifluoro-3-butenyl)malononitrile 、 sodium;hydride 、 2-bromomethyl-1,3-dichloro-5-trifluoromethylbenzene 、 以 N,N-二甲基甲酰胺 为溶剂， 以there was obtained 0.18 g of 2-(2,6-dichloro-4-(trifluoromethyl)benzyl)-2-(3,4,4-trifluoro-3-butenyl)malononitrile (the present compound (66))的产率得到2-(2,6-Dichloro-4-(trifluoromethyl)benzyl)-2-(3,4,4-trifluoro-3-butenyl)malononitrile
  参考文献：
  名称：

  Malononitrile compounds and their use as pesticides

  摘要：

  本发明涉及公式（Y）的马隆腈化合物，其中R1和R2相同或不同，分别为C1-C5（卤）烷基，C1-C5（卤）烷氧基，C2-C5（卤）烯基，C2-C5（卤）炔基，氢或氰基；R3为C1-C3卤代烷基，C2-C4卤代烯基或C2-C4卤代炔基；m是1到3的整数；R5为卤素，氰基，硝基，C1-C4（卤）烷基或类似物；n是0到4的整数，但当n为2或更多时，R5必须相同或不同；R6为氢，卤素，氰基，硝基，C1-C4（卤）烷基或类似物；以及含有这些化合物作为活性成分的杀虫剂组合物。本发明使得能够有效地控制昆虫害虫、螨害虫和线虫害虫。

  公开号：

  US20050209323A1
• 作为产物：
  描述：

  (2,6-dichloro-4-trifluoromethylphenyl)methanol 在 三溴化磷 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以96%的产率得到2-bromomethyl-1,3-dichloro-5-trifluoromethylbenzene
  参考文献：
  名称：

  WO2006/49952

  摘要：

  公开号：

文献信息

• Pesticide composition comprising malononitrile compounds
  申请人：——

  公开号：US20040142821A1

  公开（公告）日：2004-07-22

  The present invention relates to use of malononitrile compounds of formula (X): 1 wherein R 1 and R 2 are the same or different and independently C 1 -C 5 (halo)-alkyl, C 1 -C 5 (halo)alkyloxy, C 2 -C 5 (halo)alkenyl, C 2 -C 5 (halo)alkynyl, hydrogen, or cyano; R 3 and R 4 are the same or different and independently C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, or hydrogen, or R 3 and R 4 are taken together to form C 2 -C 6 (halo)alkylene or C 4 -C 6 (halo)alkenylene; R 5 is halogen, cyano, nitro, C 1 -C 4 (halo)alkyl, or the like; n is an integer of 0 to 4; R 6 is halogen, cyano, nitro, C 1 -C 4 (halo)alkyl, or the like; or R 5 and R 6 are taken together to form methylenedioxy; with the provisos that when R 6 is hydrogen, then n is an integer of 1 to 4 and that when n is 2 or more, then R 5 's are different from each other; as pesticides, and to pesticide compositions containing these compounds as active ingredients. The present invention makes it possible to effectively control pests such as insect pests, acarine pests, and nematode pests.

  本发明涉及使用式（X）的丙二腈化合物：其中R1和R2相同或不同且独立地为C1-C5（卤）烷基，C1-C5（卤）烷氧基，C2-C5（卤）烯基，C2-C5（卤）炔基，氢或氰基；R3和R4相同或不同且独立地为C1-C10烷基，C2-C10烯基，C2-C10炔基或氢，或者R3和R4结合形成C2-C6（卤）烷基或C4-C6（卤）烯基；R5为卤素，氰基，硝基，C1-C4（卤）烷基或类似物；n为0至4的整数；R6为卤素，氰基，硝基，C1-C4（卤）烷基或类似物；或者R5和R6结合形成亚甲二氧基；但当R6为氢时，n为1至4的整数，且当n为2或更多时，R5不相同；作为杀虫剂，以及含有这些化合物作为活性成分的杀虫剂组合物。本发明使得能够有效地控制害虫，例如昆虫害虫，螨虫害虫和线虫害虫。
• Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1
  申请人：Aicher Thomas Daniel

  公开号：US20080275043A1

  公开（公告）日：2008-11-06

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明公开了具有11beta-HSD type 1拮抗活性的化合物的公式I：（I），以及制备这种化合物的方法。在另一实施例中，本发明公开了包含公式I化合物的制药组合物，以及将公式I和组合物用作药物治疗糖尿病，高血糖，肥胖症，高血压，高脂血症，综合征X和与高血糖有关的其他疾病的用途。
• CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：AICHER Thomas Daniel

  公开号：US20100184764A1

  公开（公告）日：2010-07-22

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明揭示了具有11beta-HSD type 1拮抗活性的I式化合物：（I），以及制备这种化合物的方法。在另一种实施方式中，本发明揭示了包括I式化合物的制药组合物，以及将I式和组合物用作药物治疗糖尿病，高血糖，肥胖症，高血压，高脂血症，X综合症和其他与高血糖有关的疾病的用途。
• Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
  申请人：Eli Lilly and Company

  公开号：US07713979B2

  公开（公告）日：2010-05-11

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明公开了具有11beta-HSD类型1拮抗活性的I式化合物(I)，以及制备这些化合物的方法。在另一实施例中，本发明公开了包含I式化合物的药物组合物，以及将I式化合物和组合物用作药物治疗糖尿病、高血糖、肥胖症、高血压、高脂血症、X综合症以及与高血糖相关的其他病症的用途。
• EP1385377A1
  申请人：——

  公开号：EP1385377A1

  公开（公告）日：2004-02-04