4-(4-氨基苯胺基)苯酚 | 6358-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-氨基苯胺基)苯酚
• 英文名称: 4-hydroxy-4'-aminodiphenylamine
• 英文别名: 4-(4-Amino-anilino)-phenol；4-Oxy-4'-[amino-diphenylamin；p-hydroxy-p'-amino-diphenylamine；4-hydroxy 4'-aminodiphenylamine；Phenol, 4-[(4-aminophenyl)amino]-；4-(4-aminoanilino)phenol
• CAS: 6358-03-8
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: IAEZKKZBDLMWGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-氨基苯胺基)苯酚 在 碳酸氢钠 作用下， 以 乙醚 为溶剂， 生成 4-Diethylaminoethoxy-4'-isothiocyanodiphenylamin
  参考文献：
  名称：

  Isothiocyano diphenylamines

  摘要：

  公开号：

  US03755406A1
• 作为产物：
  描述：

  [1,4]benzoquinone-mono-(4-amino-phenylimine) 在 溶剂黄146 、 锌 作用下， 生成 4-(4-氨基苯胺基)苯酚
  参考文献：
  名称：

  Heller, Justus Liebigs Annalen der Chemie, 1912, vol. 392, p. 47

  摘要：

  DOI：

文献信息

• Design, Synthesis and Antitumor Activity of Novel Cis-Furoquinoline Derivatives
  作者：Jie Li、Shuchen Pei、Yingxi Zhu、Jianbo Wu、Yin Chen、Weiyu Zhang、Yong Wu

  DOI：10.2174/157018012799859909

  日期：2012.4.26

  A series of novel cis-furoquinoline derivatives was synthesized and tested for their antitumor activities in vitro against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure-activity relationships. Assay-based antiproliferative activity study revealed that several compounds had significant effects on cytotoxicity, among which compounds 2f, 2l, 2q were found to be the most active compounds. Above all, compounds 2f, 2l, 2q would be potential anticancer agents which deserved further research.

  合成了一系列新型顺式呋喃喹啉衍生物，并在体外测试了它们对 HepG2 细胞、Lu-04 细胞和 Leu02 细胞的抗肿瘤活性，以评估其结构-活性关系。基于测定法的抗增殖活性研究发现，几个化合物对细胞毒性有显著影响，其中化合物 2f、2l 和 2q 的活性最高。总之，化合物 2f、2l 和 2q 将成为潜在的抗癌药物，值得进一步研究。
• Molecular Switch Based on a Biologically Important Redox Reaction
  作者：Ping Yan、Michael W. Holman、Paul Robustelli、Arindam Chowdhury、Fady I. Ishak、David M. Adams

  DOI：10.1021/jp045793g

  日期：2005.1.1

  corroborate these quenching mechanisms. Calculations predicted photoinduced electron transfer to be energetically favorable in all cases where quenching was observed and unfavorable in all cases where it was not. Application of the perylene analogue as a biosensor has also been demonstrated by coupling the switch to the catalytic pathway of yeast alcohol dehydrogenase, a common NADH/NAD(+)-utilizing enzyme

  在我们之前关于单分子探针的报告的基础上，我们展示了如何将生物学上重要的氧化还原中心，烟酰胺和醌结合到荧光团-间隔物-受体分子结构中，形成氧化还原活性分子开关，并且每个电极都具有光诱导的电子转移行为取决于受体亚基的氧化态。基于烟酰胺（3/6）的开关在其氧化态（Phi（F）约为1.0）时具有强荧光性，但在还原态（Phi（F）<0.001）时则不发光，这是由于电子从还原性烟酰胺传递至光激发态而产生的。荧光团。通过依次用NaBH（3）CN还原并用四氯苯醌氧化，可以可逆地关闭和打开荧光，并在10个循环中以电化学方式切换，而不会发生明显的降解。相似的基于奎宁胺的开关在还原态和氧化态均显示为非荧光性：除了在还原态下的类似猝灭机制外，由于电子从荧光团转移至受体，在氧化态下也发生了猝灭。轨道能级的从头算量子化学计算被用来证实这些淬灭机理。计算预测，在观察到猝灭的所有情况下，光诱导的电子转移在能量上都是有利的
• Method for preventing polymer scale deposition in the polymerization of ethylenically unsaturated monomers
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0062230A2

  公开（公告）日：1982-10-13

  The invention provides a very efficient method with highly durable effect for preventing polymer scale deposition on the reactor walls and other surfaces coming into contact with the monomer during polymerization of an ehtylenically unsaturated polymerizable monomer in an aqueous medium such as in the suspension polymerization of vinyl chloride. The method comprises coating the reactor walls, prior to polymerization, with a novel coating material which is a condensation product obtained by the condensation reaction of an aromatic amine compound such as aniline and an aromatic nitro compound such as nitrobenzene in the presence of a mineral acid and a specified condensation catalyst. It is sometimes preferable that the condensation product is basified or treated with an alkali or ammonium compound to be imparted with a modified solubility behavior.

  本发明提供了一种非常有效的方法，具有非常持久的效果，可在水介质中聚合乙 烯基不饱和可聚合单体（如氯乙烯的悬浮聚合）时，防止聚合物垢沉积在反应器壁 和与单体接触的其他表面上。该方法包括在聚合之前在反应器壁上涂覆一种新型涂层材料，该材料是芳香族胺化合物（如苯胺）和芳香族硝基化合物（如硝基苯）在矿物酸和特定缩合催化剂存在下发生缩合反应而得到的缩合产物。有时最好将缩合产物碱化或用碱或铵化合物处理，以改变其溶解性。
• Method for preventing scale deposition in the polymerization of ethylenically unsaturated monomers
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0096319A1

  公开（公告）日：1983-12-21

  The invention provides a method for preventing polymer scale build-up on the reactor walls, in particular, in the suspension or emulsion polymerization of an ethylenically unsaturated monomer effective even in the cases where the polymerization initator is a monomer-soluble organic peroxide having a relatively high solubility in water which hitherto has been not used due to the difficulty in preventing polymer scale build-up despite the superior quality of the polymer product obtained therewith. The method comprises coating the reactor walls in advance with an aqueous coating composition comprising (t) an organic dye of sulfonic or carboxylic acid type in the form of an alkali metal or ammonium salt and (II) an aqueous colloidal dispersion of an inorganic material and then drying the coated surface.

  本发明提供了一种防止聚合物在反应器壁上结垢的方法，特别是在乙烯基不饱和单体的悬浮聚合或乳液聚合中，即使聚合引发剂是在水中溶解度较高的单体可溶性有机过氧化物，也能有效防止聚合物结垢。该方法包括预先在反应器壁上涂一层水性涂层组合物，该组合物包括 (t) 一种碱金属盐或铵盐形式的磺酸或羧酸类有机染料和 (II) 一种无机材料的水性胶体分散液，然后将涂层表面干燥。
• Method and test composition for determination of hydrogen peroxide
  申请人：Kyowa Medex Co. Ltd.

  公开号：EP0124287A2

  公开（公告）日：1984-11-07

  Disclosed is a method for the colorimetric determination of hydrogen peroxide in a sample by reacting a particular chromogen with the hydrogen peroxide in the presence of peroxidase and measuring the absorbancy of the reaction solution in the visible or near inflared ray region. Also disclosed is a test composition for carrying out the determination. The novel chromogens are represented by the formulae

  本发明公开了一种用比色法测定样品中过氧化氢的方法，该方法是在过氧化物酶的存在下，使一种特定的发色剂与过氧化氢反应，并测量反应溶液在可见光或近红外线区域的吸光度。 本发明还公开了一种用于进行该测定的测试组合物。 新型发色剂由以下式子表示