(3aS,4S,4aS,6S,7aS,9aS)-1-methoxy-6-vinyl-1,3,3a,4,4a,5,6,7,7a,9a-decahydroazuleno[5,6-c]furan-4-ol | 1070804-04-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (3aS,4S,4aS,6S,7aS,9aS)-1-methoxy-6-vinyl-1,3,3a,4,4a,5,6,7,7a,9a-decahydroazuleno[5,6-c]furan-4-ol
• CAS: 1070804-04-4
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: XPDXJLIHDHHWOM-ZLGMVYLJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.98
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (3aS,4S,4aS,6S,7aS,9aS)-1-methoxy-6-vinyl-1,3,3a,4,4a,5,6,7,7a,9a-decahydroazuleno[5,6-c]furan-4-ol 、 叔丁基二甲基氯硅烷 在 2,6-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到tert-butyl(((3aS,4S,4aS,6S,7aS,9aS)-1-methoxy-6-vinyl-1,3,3a,4,4a,5,6,7,7a,9a-decahydroazuleno[5,6-c]furan-4-yl)oxy)dimethylsilane
  参考文献：
  名称：

  A novel asymmetric approach to a densely functionalized lactarane ring system through a domino ring opening–ring closing metathesis of a norbornene derivative

  摘要：

  A novel route for the synthesis of a highly functionalized lactarane skeleton in enantiomerically pure form is described via ROM-RCM of an appropriately constructed norbornene derivative as the key step. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.083
• 作为产物：
  描述：

  甲醇 、 (3aS,5aS,7S,8aS,9S,9aS)-7-ethenyl-1,3,3a,5a,6,7,8,8a,9,9a-decahydroazuleno[5,6-c]furan-3,9-diol 在 盐酸 作用下， 以70%的产率得到(3aS,4S,4aS,6S,7aS,9aS)-1-methoxy-6-vinyl-1,3,3a,4,4a,5,6,7,7a,9a-decahydroazuleno[5,6-c]furan-4-ol
  参考文献：
  名称：

  A novel asymmetric approach to a densely functionalized lactarane ring system through a domino ring opening–ring closing metathesis of a norbornene derivative

  摘要：

  A novel route for the synthesis of a highly functionalized lactarane skeleton in enantiomerically pure form is described via ROM-RCM of an appropriately constructed norbornene derivative as the key step. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.07.083