8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone | 233746-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone
• 英文别名: 6,13-Ditert-butyl-15,16-dimethoxytricyclo[9.3.1.14,8]hexadeca-1(14),4,6,8(16),11(15),12-hexaene-2,3,9,10-tetrone；6,13-ditert-butyl-15,16-dimethoxytricyclo[9.3.1.14,8]hexadeca-1(14),4,6,8(16),11(15),12-hexaene-2,3,9,10-tetrone
• CAS: 233746-56-0
• 化学式: C₂₆H₂₈O₆
• 分子量: 436.505
• InChiKey: HFLGWOGSOAYRNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以71%的产率得到8,16-dimethyl-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone
  参考文献：
  名称：

  Synthesis of 8,16-dimethyl- and 8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone

  摘要：

  Swern oxidation of 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl-1,2,9,10-tetrahydroxy[2.2]metacyclophane, 1 and 2, afforded 5,13-di-t-butyl-10-hydroxy-8,16-dimethoxy[2.2]metacyclophane-1,2,9-trione 3 and 4. By subsequent oxidation with DDQ, 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraones, 5 and 6, were obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00845-x
• 作为产物：
  描述：

  5,13-di-t-butyl-10-hydroxy-8,16-dimethoxy[2.2]metacyclophane-1,2,9-trione 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以55%的产率得到8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone
  参考文献：
  名称：

  Synthesis of 8,16-dimethyl- and 8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone

  摘要：

  Swern oxidation of 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl-1,2,9,10-tetrahydroxy[2.2]metacyclophane, 1 and 2, afforded 5,13-di-t-butyl-10-hydroxy-8,16-dimethoxy[2.2]metacyclophane-1,2,9-trione 3 and 4. By subsequent oxidation with DDQ, 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraones, 5 and 6, were obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00845-x

文献信息

• Synthesis of 8,16-dimethyl- and 8,16-dimethoxy-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraone
  作者：Ken-ichi Tsukamoto、Daniel A. Sahade、Masahiko Taniguchi、Tsuyoshi Sawada、Thies Thiemann、Shuntaro Mataka

  DOI：10.1016/s0040-4039(99)00845-x

  日期：1999.6

  Swern oxidation of 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl-1,2,9,10-tetrahydroxy[2.2]metacyclophane, 1 and 2, afforded 5,13-di-t-butyl-10-hydroxy-8,16-dimethoxy[2.2]metacyclophane-1,2,9-trione 3 and 4. By subsequent oxidation with DDQ, 8,16-dimethoxy- and 8,16-dimethyl-5,13-di-t-butyl[2.2]metacyclophane-1,2,9,10-tetraones, 5 and 6, were obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.