Ammonium perfluoro-6-methylheptanoate | 19742-57-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ammonium perfluoro-6-methylheptanoate
• 英文别名: azanium;2,2,3,3,4,4,5,5,6,7,7,7-dodecafluoro-6-(trifluoromethyl)heptanoate
• CAS: 19742-57-5
• 化学式: C8H4F15NO2
• 分子量: 431.1
• InChiKey: FEPNWJQHVCVVDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.49
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  41.1
• 氢给体数：
  1
• 氢受体数：
  17

文献信息

• PHARMACEUTICAL COMPOSITIONS CONTAINING FLUORINATED OR PERFLUORINATED CARBOXYLIC ACIDS
  申请人：ELCOMBE CLIFFORD R.

  公开号：US20120029079A1

  公开（公告）日：2012-02-02

  The molecules of formula (I) are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipis of eicosanoid status or functions may be desirable. Formula (I): Z 1 —Z 1 —Z 2 wherein a) Z 1 represents CO 2 H or a derivative thereof; b) Z 2 represents F, H, —CO 2 H or a derivative thereof; and c) X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

  式(I)的分子在治疗糖尿病、肥胖症、高胆固醇血症、高脂血症、癌症、炎症或其他需要调节脂质或前列腺素状态或功能的情况中是有用的。式(I)：Z1—Z1—Z2其中a) Z1表示CO2H或其衍生物；b) Z2表示F、H、—CO2H或其衍生物；c) X表示氟化烷基；或其溶剂化物，例如全氟脂肪酸或其衍生物。
• Methods
  申请人：Elcombe Clifford Roy

  公开号：US20100240751A1

  公开（公告）日：2010-09-23

  A perfluoroctanoic acid or a salt or an ester thereof; perfluorosuberic acid, perfluoroheptanoic acid, perfluorohexanoic acid, perfluoropentanoic acid, perfluorobutanoic acid or perfluoropropionic acid or a salt or an ester any thereof; or perfluoroctane are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable.

  全氟辛酸或其盐或酯；全氟戊二酸、全氟庚酸、全氟己酸、全氟戊酸、全氟丁酸或全氟丙酸或其盐或酯；或全氟辛烷可用于治疗糖尿病、肥胖症、高胆固醇血症、高脂血症、癌症、炎症或其他需要调节脂质或前列腺素状态或功能的疾病。
• Uses of perfluorinated carboylic acid derivatives for the manufacture of a medicament for the modulation of body mass
  申请人：CXR BIOSCIENCES LIMITED

  公开号：EP1745779A2

  公开（公告）日：2007-01-24

  The molecules of formula I are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable. Formula I:          Z1-X-Z2     I wherein Z1 represents -CO2H or a derivative thereof; Z2 represents F, H, -CO2H or a derivative thereof; and X represents fluorinated alkylene; or a solvate thereof, for example a perfluorinated fatty acid or derivative thereof.

  式 I 分子可用于治疗糖尿病、肥胖症、高胆固醇血症、高脂血症、癌症、炎症或其他需要调节脂质或类二十烷状态或功能的疾病。 式 I： Z1-X-Z2 I 其中 Z1 代表 -CO2H 或其衍生物； Z2 代表 F、H、-CO2H 或其衍生物；以及 X 代表氟化亚烷基； 或其溶解物、 例如全氟脂肪酸或其衍生物。
• PERFLUORINATED FATTY ACIDS FOR THE TREATMENT OF OBESITY, DIABETES, HYPERLIPIDAEMIA, CANCER AND INFLAMMATION
  申请人：CXR BIOSCIENCES LIMITED

  公开号：EP1534260A2

  公开（公告）日：2005-06-01
• Method
  申请人：Elcombe Roy Clifford

  公开号：US20060052451A1

  公开（公告）日：2006-03-09

  A perfluoroctanoic acid or a salt or an ester thereof, perfluorosuberic acid, perfluoroheptanoic acid, perfluorohexanoic acid, perfluoropentanoic acid, perfluorobutanoic acid or perfluoropropionic acid or a salt or an ester any thereof, or perfluoroctane are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable.