5-(3-fluorophenyl)-1-methyl-1,3-dihydro-2H-indol-2-one | 1299028-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(3-fluorophenyl)-1-methyl-1,3-dihydro-2H-indol-2-one
• 英文别名: 5-(3-fluorophenyl)-1-methyl-3H-indol-2-one
• CAS: 1299028-27-5
• 化学式: C₁₅H₁₂FNO
• 分子量: 241.265
• InChiKey: QNHMSKJFZIRANW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SUBSTITUTED HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES SUBSTITUÉS
  申请人：GILEAD SCIENCES INC

  公开号：WO2011056985A2

  公开（公告）日：2011-05-12

  The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I) as further described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.