诃子林鞣酸 | 18942-26-2

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 中文名称: 诃子林鞣酸
• 英文名称: 2-[(4R,5S,7R,8R,11S,12S,13R)-13,17,18-trihydroxy-2,10,14-trioxo-5,21-bis[(3,4,5-trihydroxybenzoyl)oxy]-7-[(3,4,5-trihydroxybenzoyl)oxymethyl]-3,6,9,15-tetraoxatetracyclo[10.7.1.14,8.016,20]henicosa-1(19),16(20),17-trien-11-yl]acetic acid
• CAS: 18942-26-2
• 化学式: C₄₁H₃₂O₂₇
• 分子量: 956.7
• InChiKey: YGVHOSGNOYKRIH-REKMSKHASA-N

物化性质

• 沸点：
  1460.0±65.0 °C(Predicted)
• 密度：
  2.04
• 溶解度：
  溶于丙酮、甲醇和热水；不溶于氯仿和正己烷

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂，也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。

靶点

target: M. tuberculosis DNA gyrase[1], SMAD-3 phosphorylation[2], H+ K+-ATPase activity.[3] IC50: 65.01 μg/ml ( H+ K+-ATPase ) [3]

体外研究

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. [1] Chebulinic acid reduce the expression and activity of MMP-2 at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. [2] chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml. [3]

化学性质 

白色结晶粉末。

用途 

用于含量测定/鉴定/药理实验等。