Naloxone benzoylhydrazone | 119630-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Naloxone benzoylhydrazone
• 英文别名: N-[(E)-[(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ylidene]amino]benzamide
• CAS: 119630-94-3
• 化学式: C₂₆H₂₇N₃O₄
• 分子量: 445.5
• InChiKey: AKXCFAYOTIEFOH-XTNAHFASSA-N

物化性质

• 密度：
  1.44±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  94.4
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• WGK Germany：
  3

文献信息

• [EN] METHOD FOR INHIBITING GROWTH OF CANCER CELLS<br/>[FR] PROCÉDÉ POUR INHIBER LA CROISSANCE DE CELLULES CANCÉREUSES
  申请人：PAIN THERAPEUTICS INC

  公开号：WO2015054027A1

  公开（公告）日：2015-04-16

  1 A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Aktl, ERK2 and serine2152-phosphorylated filamin A are contacted with an FLNA-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of filamin A (FLNA) of SEQ ID NO: 1 and exhibits at least about 60 percent of the FITC- labeled naloxone binding amount when present at a 10 μΜ concentration and using unlabeled naloxone as the control inhibitor at the same concentration. A compound that binds to the FLNA pentapeptide preferably also contains at least four of the six pharmacophores of Figs. 19-24.

  本发明揭示了一种抑制癌细胞生长的方法，其中将相对于非癌细胞含有增强量的一个或多个磷酸化mTOR、Aktl、ERK2和丝氨酸2152-磷酸化filamin A的癌细胞与与filamin A（FLNA）的SEQ ID NO: 1的五肽结合并且在10μΜ浓度下至少表现出FITC标记的纳洛酮结合量的60％的化合物或其药学上可接受的盐接触。优选结合到FLNA五肽的化合物还包含Figs. 19-24中的六个药效团中的至少四个。
• Alzheimer's disease assay in a living patient
  申请人：Pain Therapeutics, Inc.

  公开号：US11385221B2

  公开（公告）日：2022-07-12

  An assay for Alzheimer's disease (AD) pathology in a living patient is disclosed wherein an amount of α7nAChR or TLR4 in a FLNA-captured protein complex or α7nAChR in an Aβ-captured protein complex or α7nAChR-FLNA, or TLR4-FLNA and/or α7nAChR-Aβ42 complex present as a protein-protein complex in a sample is compared to the amount in a standard sample from a person free of AD pathology. An amount greater than in the standard sample indicates AD pathology. Also disclosed is an assay predictive of prognosis for treatment with a medicament in which the amount of an above protein or protein complex is compared to an amount in the presence of a medicament that binds to a FLNA pentapeptide and contains at least four pharmacophores of FIGS. 7-12. An amount of protein or protein complex determined in the presence of medicament that is less than the first amount indicates a favorable treatment prognosis.

  本发明公开了一种活体患者阿尔茨海默病（AD）病理检测方法，其中将样品中FLNA捕获蛋白复合物中的α7nAChR或TLR4，或Aβ捕获蛋白复合物中的α7nAChR，或α7nAChR-FLNA，或TLR4-FLNA和/或α7nAChR-Aβ42复合物中作为蛋白-蛋白复合物存在的α7nAChR或TLR4的量与无AD病理的人的标准样品中的量进行比较。如果含量大于标准样本中的含量，则表明存在 AD 病变。还公开了一种预测药物治疗预后的检测方法，其中将上述蛋白或蛋白复合物的量与存在与FLNA五肽结合并含有图7-12中至少四种药效团的药物时的量进行比较。如果在有药物存在的情况下测定的蛋白质或蛋白质复合物的量小于第一量，则表明治疗预后良好。
• ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT
  申请人：WANG HOAU-YAN

  公开号：US20140017698A1

  公开（公告）日：2014-01-16

  An assay for Alzheimer's disease (AD) pathology in a living patient is disclosed wherein an amount of α7nAChR or TLR4 in a FLNA-captured protein complex or α7nAChR in an Aβ-captured protein complex or α7nAChR-FLNA, or TLR4-FLNA and/or α7nAChR-Aβ 42 complex present as a protein-protein complex in a sample is compared to the amount in a standard sample from a person free of AD pathology. An amount greater than in the standard sample indicates AD pathology. Also disclosed is an assay predictive of prognosis for treatment with a medicament in which the amount of an above protein or protein complex is compared to an amount in the presence of a medicament that binds to a FLNA pentapeptide and contains at least four pharmacophores of FIGS. 7 - 12 . An amount of protein or protein complex determined in the presence of medicament that is less than the first amount indicates a favorable treatment prognosis.
• METHOD FOR INHIBITING GROWTH OF CANCER CELLS
  申请人：Pain Therapeutics, Inc.

  公开号：US20150148318A1

  公开（公告）日：2015-05-28

  A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Akt1, ERK2 and serine2152-phosphorylated filamin A are contacted with an FLNA-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of filamin A (FLNA) of SEQ ID NO: 1 and exhibits at least about 60 percent of the FITC-labeled naloxone binding amount when present at a 10 μM concentration and using unlabeled naloxone as the control inhibitor at the same concentration. A compound that binds to the FLNA pentapeptide preferably also contains at least four of the six pharmacophores of FIGS. 19 - 24.
• US9354223B2
  申请人：——

  公开号：US9354223B2

  公开（公告）日：2016-05-31