N-((1-(3-(3-((thiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methylene)thiazol-2-amine | 1447152-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-((1-(3-(3-((thiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methylene)thiazol-2-amine
• 英文别名: N-(1,3-thiazol-2-yl)-1-[1-[3-[3-(1,3-thiazol-2-yliminomethyl)indol-1-yl]propyl]indol-3-yl]methanimine
• CAS: 1447152-10-4
• 化学式: C₂₇H₂₂N₆S₂
• 分子量: 494.644
• InChiKey: YAUUBESSJCMWSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基噻唑 、 1,1'-(propane-1,3-diyl)bis(1H-indole-3-carbaldehyde) 以 甲醇 为溶剂， 反应 1.0h， 以79%的产率得到N-((1-(3-(3-((thiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methylene)thiazol-2-amine
  参考文献：
  名称：

  Biologically active Schiff bases as potentiometric sensor for the selective determination of Nd3+ ion

  摘要：

  Novel multidentate Schiff bases 5-((1-(3-(3-((5-mercapto-1,3,4-thiadiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methyleneamino)-1,3,4-thiadiazole-2-thiol) (S-1) and N-((1-(3-(3-((thiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methylene)thiazol-2-amine (S-2) were synthesized for the construction of Nd3+ ion-selective electrode. The polymeric membrane electrodes (PME) were fabricated along with various plasticizers and additive. It is found that the PME based on S-1 having the composition (S-1 : (potassium tetrakis p-(chloro phenyl)borate) KTpCIPB: (o-nitrophenyloctyl ether) o-NPOE: PVC 4:2:58:36, w/w, mg) is found to be better. Thus, the coated graphite electrode (CGE) was constructed with the same composition and the results were compared with PME. The CGE is found to be better in comparison to PME with respect to all the potentiometric characteristics such as low detection limit (1.1 x 10(-8) mol L-1), wide working concentration range (3.1 x 10(-8)-1.0 x 10(-1) mol L-1), near Nernstian slope (19.8 +/- 0.3 mV decade(-1) of activity.), low response time (10 s), shelf life time (105 days) and wide pH range (3.5-8.0). Both the PME and CGE were used for the quantifying the Nd3+ ion in various samples such as water, soil samples, binary mixtures and as an indicator electrode using EDTA. PME and CGE were also used for the determination of F- ion in mouth wash solution and tooth paste sample. Further the antibacterial activity of Schiff bases were examined by broth micro-dilution method and found that these are antibiotics against Staphylococcus aureus (Gram positive) and Escherichia coli (ATCC25922) (Gram negative). (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.electacta.2013.05.038

文献信息

• Biologically active Schiff bases as potentiometric sensor for the selective determination of Nd3+ ion
  作者：Koteswara Rao Bandi、Ashok Kumar Singh、Anjali Upadhyay

  DOI：10.1016/j.electacta.2013.05.038

  日期：2013.8

  Novel multidentate Schiff bases 5-((1-(3-(3-((5-mercapto-1,3,4-thiadiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methyleneamino)-1,3,4-thiadiazole-2-thiol) (S-1) and N-((1-(3-(3-((thiazol-2-ylimino)methyl)-1H-indol-1-yl)propyl)-1H-indol-3-yl)methylene)thiazol-2-amine (S-2) were synthesized for the construction of Nd3+ ion-selective electrode. The polymeric membrane electrodes (PME) were fabricated along with various plasticizers and additive. It is found that the PME based on S-1 having the composition (S-1 : (potassium tetrakis p-(chloro phenyl)borate) KTpCIPB: (o-nitrophenyloctyl ether) o-NPOE: PVC 4:2:58:36, w/w, mg) is found to be better. Thus, the coated graphite electrode (CGE) was constructed with the same composition and the results were compared with PME. The CGE is found to be better in comparison to PME with respect to all the potentiometric characteristics such as low detection limit (1.1 x 10(-8) mol L-1), wide working concentration range (3.1 x 10(-8)-1.0 x 10(-1) mol L-1), near Nernstian slope (19.8 +/- 0.3 mV decade(-1) of activity.), low response time (10 s), shelf life time (105 days) and wide pH range (3.5-8.0). Both the PME and CGE were used for the quantifying the Nd3+ ion in various samples such as water, soil samples, binary mixtures and as an indicator electrode using EDTA. PME and CGE were also used for the determination of F- ion in mouth wash solution and tooth paste sample. Further the antibacterial activity of Schiff bases were examined by broth micro-dilution method and found that these are antibiotics against Staphylococcus aureus (Gram positive) and Escherichia coli (ATCC25922) (Gram negative). (c) 2013 Elsevier Ltd. All rights reserved.