(E)-2-<3,9-diaza-11-<4-(2-chloro-1,2-diphenylethenyl)phenoxy>-2-oxo-9-(tert-butyloxycarbonyl)undecamethylene>-9-methoxyellipticinium chloride | 95764-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-2-<3,9-diaza-11-<4-(2-chloro-1,2-diphenylethenyl)phenoxy>-2-oxo-9-(tert-butyloxycarbonyl)undecamethylene>-9-methoxyellipticinium chloride
• CAS: 95764-48-0
• 化学式: C₅₂H₅₆ClN₄O₅*Cl
• 分子量: 887.946
• InChiKey: MNSRDGCBFCGTKG-KRJAOJSISA-N

反应信息

• 作为反应物：
  描述：

  (E)-2-<3,9-diaza-11-<4-(2-chloro-1,2-diphenylethenyl)phenoxy>-2-oxo-9-(tert-butyloxycarbonyl)undecamethylene>-9-methoxyellipticinium chloride 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 以82%的产率得到(E)-2-<3,9-diaza-11-<4-(2-chloro-1,2-diphenylethenyl)phenoxy>-2-oxoundecamethylene>-9-methoxyellipticinium chloride hydrochloride
  参考文献：
  名称：

  Isoxazoles with antipicornavirus activity

  摘要：

  The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to 22% for the nonmedicated animals.

  DOI：

  10.1021/jm00383a010