trans-1,2-epoxy-4-hydroxycyclohexane | 2461-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: trans-1,2-epoxy-4-hydroxycyclohexane
• 英文别名: 7-Oxabicyclo[4.1.0]heptan-3-ol
• CAS: 2461-22-5
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: OULAQVCZRNCPNC-UHFFFAOYSA-N

物化性质

• 沸点：
  248.7±8.0 °C(Predicted)
• 密度：
  1.224±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-1,2-epoxy-4-hydroxycyclohexane 在 吡啶 作用下， 以 氘代氯仿 、 苯 为溶剂， 反应 3.33h， 生成 4-hydroxy-2-cyclohexenone
  参考文献：
  名称：

  A photochemical synthesis of βγ-epoxycyclohexanones

  摘要：

  DOI：

  10.1016/s0040-4039(00)81340-4
• 作为产物：
  描述：

  1,4-环己二醇 在 sodium carbonate 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 trans-1,2-epoxy-4-hydroxycyclohexane
  参考文献：
  名称：

  A photochemical synthesis of βγ-epoxycyclohexanones

  摘要：

  DOI：

  10.1016/s0040-4039(00)81340-4

文献信息

• Pyrrolotriazine compounds
  申请人：Gavai V. Ashvinikumar

  公开号：US20060014745A1

  公开（公告）日：2006-01-19

  The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

  本发明提供了式I的化合物及其药用盐。本发明的化合物抑制酪氨酸激酶活性，如HER1、HER2和HER4等生长因子受体，因此使它们可用作抗增殖剂。这些化合物还可用于治疗与通过生长因子受体进行信号转导途径相关的其他疾病。
• [EN] A PROCESS FOR PREPARING AN OPTICALLY ACTIVE CINEOLE DERIVATIVE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN DÉRIVÉ DE CINÉOLE OPTIQUEMENT ACTIF
  申请人：BASF AGRO BV

  公开号：WO2018210662A1

  公开（公告）日：2018-11-22

  The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9 % that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.

  本发明涉及一种通过酶解和手性纯度大于99.9%的光学活性1,4-桉叶醇衍生物的制备过程。本发明还涉及一种从手性纯度高的光学活性1,4-桉叶醇衍生物制备7-氧杂双环[2.2.1]庚烷衍生物的过程。
• Stereoselective expoxidation of allylic and homoallylic alcohols with 30% hydrogen peroxide catalyzed by tungstic acid in buffered media
  作者：Denis Prat、Bernard Delpech、Robert Lett

  DOI：10.1016/s0040-4039(00)84080-0

  日期：1986.1

  The aqueous tungstic acid-catalyzed hydrogen peroxide epoxidation of allylic alcohols affords the same major diastereoisomer as the VO(acac)2/tBuOOH system with quite comparable stereoselectivities. In contrast, epoxidation of homoallylic alcohols appears to be much less stereoselective.

  钨酸催化的烯丙醇过氧化氢环氧化可提供与VO（acac）2 / tBuOOH体系相同的主要非对映异构体，且具有相当的立体选择性。相反，均烯丙基醇的环氧化似乎立体选择性低得多。
• [EN] (AZIRIDINYL HYDROXY)-FUNCTIONAL ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES FONCTIONNELS D'(AZIRIDINYLE HYDROXY)
  申请人：COVESTRO NETHERLANDS BV

  公开号：WO2021148558A1

  公开（公告）日：2021-07-29

  The invention relates to particular (aziridinyl hydroxy)-functional organic component. The invention further relates to liquid compositions comprising said (aziridinyl hydroxy)-functional organic component. The invention further relates to coating compositions comprising said (aziridinyl hydroxy)-functional organic component. The invention further relates to liquid coating compositions comprising said (aziridinyl hydroxy)-functional organic component. The invention further relates to a kit-of-parts comprising in one of its parts a liquid composition comprising a particular (aziridinyl hydroxy)-functional organic component. The invention further relates to cured forms of said liquid compositions, coating compositions, and liquid coating compositions. The invention further relates to articles comprising the (aziridinyl hydroxy)-functional organic component and/or the liquid compositions and/or the liquid coating compositions and/or their cured forms. The invention further relates to various uses of the (aziridinyl hydroxy)- functional organic component and/or said liquid compositions, and/or said liquid coating compositions, and/or said kit-of-parts and/or said cured forms.

  该发明涉及特定的（环氧环丙基羟基）-功能有机组分。该发明还涉及包含所述（环氧环丙基羟基）-功能有机组分的液体组合物。该发明还涉及包含所述（环氧环丙基羟基）-功能有机组分的涂料组合物。该发明还涉及包含所述（环氧环丙基羟基）-功能有机组分的液体涂料组合物。该发明还涉及一种部件中包含液体组合物的套件，所述液体组合物包含特定的（环氧环丙基羟基）-功能有机组分。该发明还涉及所述液体组合物、涂料组合物和液体涂料组合物的固化形式。该发明还涉及包含（环氧环丙基羟基）-功能有机组分和/或液体组合物和/或液体涂料组合物和/或其固化形式的物品。该发明还涉及（环氧环丙基羟基）-功能有机组分和/或所述液体组合物和/或所述液体涂料组合物和/或所述套件和/或所述固化形式的各种用途。
• Oxidation of alcohols with oxoperoxobis(N-phenylbenzohydroxamato)molybdenum(VI)
  作者：Hiroki Tomioka、Kazuhiko Takai、Koichiro Oshima、Hitosi Nozaki、Koshiro Toriumi

  DOI：10.1016/0040-4039(80)80154-7

  日期：1980.1

  The title complex oxidizes primary and secondary alcohols to the corresponding carbonyl compounds. Stereoselective epoxidation of allylic alcohols is also described.

  标题络合物将伯醇和仲醇氧化为相应的羰基化合物。还描述了烯丙醇的立体选择性环氧化。