H-L-Ala-Aib-OH | 84799-80-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-L-Ala-Aib-OH
• 英文别名: H-Ala-Aib-OH；α-L-alanylamino-isobutyric acid；α-L-Alanylamino-isobuttersaeure；α-(L-2-Amino-propionylamino)-isobuttersaeure；2-[[(2S)-2-aminopropanoyl]amino]-2-methylpropanoic acid
• CAS: 84799-80-4
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: LXQBKFVOZBRFEP-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 钯 、 溶剂黄146 作用下， 生成 H-L-Ala-Aib-OH
  参考文献：
  名称：

  Bergmann et al., Journal of Biological Chemistry, 1935, vol. 109, p. 344

  摘要：

  DOI：

文献信息

• Pancreatic polypeptide family motifs and polypeptides comprising the same
  申请人：Amylin Pharmaceuticals Inc.

  公开号：EP2335715A2

  公开（公告）日：2011-06-22

  The present invention relates to novel Pancreatic Polypeptide Family ("PPF") polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50 % sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.

  本发明涉及新型胰多肽家族（"PPF"）多肽。本发明的 PPF 多肽一般至少包括两个 PPF 基序，在其长度上与PYY（3-36）至少有 50%的序列相同性，并且一般至少部分保留 PP 的生物活性、本发明优选的 PPF 多肽是那些在本文所述的一种检测方法（最好是食物摄入、胃排空、胰腺分泌或体重减轻检测方法）中的效力大于 PP、NPY、PYY 或 PYY（3-36）在相同检测方法中的效力的多肽。一方面，本发明的 PPF 多肽包括新型PYY 类似物多肽。另一个方面，本发明的 PPF 多肽包括 PPF 嵌合多肽，包括与第二个 PP 家族多肽连接的 PP 家族多肽片段，其中第一和第二片段中的每一个都包括 PPF 基序。还公开了使用本发明 PPF 多肽的方法和包括本发明 PPF 多肽的药物组合物。
• PANCREATIC POLYPEPTIDE FAMILY MOTIFS AND POLYPEPTIDES COMPRISING THE SAME
  申请人：AMYLIN PHARMACEUTICALS, INC.

  公开号：EP1789440A2

  公开（公告）日：2007-05-30
• EP1789440A4
  申请人：——

  公开号：EP1789440A4

  公开（公告）日：2008-03-12
• [EN] PANCREATIC POLYPEPTIDE FAMILY MOTIFS AND POLYPEPTIDES COMPRISING THE SAME<br/>[FR] MOTIFS DE LA FAMILLE DE POLYPEPTIDES PANCREATIQUES ET POLYPEPTIDES LES RENFERMANT
  申请人：AMYLIN PHARMACEUTICALS INC

  公开号：WO2005077094A2

  公开（公告）日：2005-08-25

  The present invention relates to novel Pancreatic Polypeptide Family ('PPF') polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50 % sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.
• Bergmann et al., Journal of Biological Chemistry, 1935, vol. 109, p. 344
  作者：Bergmann et al.

  DOI：——

  日期：——