2-<2-(2-hydroxyethoxy)phenoxy>pentan-1-ol | 84433-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-<2-(2-hydroxyethoxy)phenoxy>pentan-1-ol
• 英文别名: 2-[2-(2-hydroxyethoxy)phenoxy]pentan-1-ol
• CAS: 84433-57-8
• 化学式: C₁₃H₂₀O₄
• 分子量: 240.299
• InChiKey: FWGYQSLZOVWJTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  二乙二醇双对甲苯磺酸酯 、 2-<2-(2-hydroxyethoxy)phenoxy>pentan-1-ol 在 sodium hydride 作用下， 生成 5-n-propyl-2,3-benzo-15-crown-5
  参考文献：
  名称：

  Anticoccidial activity of crown polyethers

  摘要：

  Anticoccidial activity in vitro against Eimeria tenella is reported for crown polyethers with ring sizes from 14 to 30 atoms. The most potent compounds, 4 and 9, were found active at 0.33 ppm, but none were active in vivo. Test results are discussed in terms of lipophilic shielding of complexed cations.

  DOI：

  10.1021/jm00358a025
• 作为产物：
  描述：

  ethyl 2-<2-<(ethoxycarbonyl)methoxy>phenoxy>valerate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以82%的产率得到2-<2-(2-hydroxyethoxy)phenoxy>pentan-1-ol
  参考文献：
  名称：

  Anticoccidial activity of crown polyethers

  摘要：

  Anticoccidial activity in vitro against Eimeria tenella is reported for crown polyethers with ring sizes from 14 to 30 atoms. The most potent compounds, 4 and 9, were found active at 0.33 ppm, but none were active in vivo. Test results are discussed in terms of lipophilic shielding of complexed cations.

  DOI：

  10.1021/jm00358a025

文献信息

• BROWN, G. R.;FOUBISTER, A. J., J. MED. CHEM., 1983, 26, N 4, 590-592
  作者：BROWN, G. R.、FOUBISTER, A. J.

  DOI：——

  日期：——