butyl (5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-3-oxo-6-(phenylmethoxycarbonylamino)heptanoate | 1053245-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butyl (5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-3-oxo-6-(phenylmethoxycarbonylamino)heptanoate
• CAS: 1053245-45-6
• 化学式: C₂₅H₄₁NO₇Si
• 分子量: 495.689
• InChiKey: LNQYZGSLZKUTBN-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  34
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  butyl (5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-3-oxo-6-(phenylmethoxycarbonylamino)heptanoate 在 三乙酰氧基硼氢化钠 作用下， 以 溶剂黄146 、 乙腈 为溶剂， 生成 N-(Z)-galantinic butyl ester
  参考文献：
  名称：

  A straightforward enantiospecific synthesis of N-(Z)-galantinic butyl ester

  摘要：

  A short and efficient access to the naturally occurring amino acid galantinic acid is reported using two highly diastereoselective reactions, namely a vinylogous Mukaiyama reaction and a 1,3-hydroxy directed Evans reduction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00753-5
• 作为产物：
  描述：

  [(2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-ethyl]-carbamic acid benzyl ester 在 Eu(fod)3 作用下， 以 二氯甲烷 为溶剂， 生成 butyl (5S,6S)-7-[tert-butyl(dimethyl)silyl]oxy-5-hydroxy-3-oxo-6-(phenylmethoxycarbonylamino)heptanoate
  参考文献：
  名称：

  A straightforward enantiospecific synthesis of N-(Z)-galantinic butyl ester

  摘要：

  A short and efficient access to the naturally occurring amino acid galantinic acid is reported using two highly diastereoselective reactions, namely a vinylogous Mukaiyama reaction and a 1,3-hydroxy directed Evans reduction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00753-5

文献信息

• A straightforward enantiospecific synthesis of N-(Z)-galantinic butyl ester
  作者：Xavier Moreau、Jean-Marc Campagne

  DOI：10.1016/s0040-4039(01)00753-5

  日期：2001.7

  A short and efficient access to the naturally occurring amino acid galantinic acid is reported using two highly diastereoselective reactions, namely a vinylogous Mukaiyama reaction and a 1,3-hydroxy directed Evans reduction. (C) 2001 Elsevier Science Ltd. All rights reserved.