tert-butyl (R)-2-isobutyl-4-methylenepyrrolidine-2-carboxylate | 1186301-84-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (R)-2-isobutyl-4-methylenepyrrolidine-2-carboxylate
• CAS: 1186301-84-7
• 化学式: C₁₄H₂₅NO₂
• 分子量: 239.358
• InChiKey: YLHCSEKQRGUIJS-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  在 sodium carbonate 作用下， 生成 tert-butyl (R)-2-isobutyl-4-methylenepyrrolidine-2-carboxylate
  参考文献：
  名称：

  Catalytic asymmetric synthesis of cyclic α-alkyl-amino acid derivatives having a tetrasubstituted α-carbon

  摘要：

  Catalytic asymmetric synthesis of various cyclic alpha-alkyl-amino acid derivatives having a tetrasubstituted alpha-carbon has been accomplished by the utilization of phase-transfer alkylation of alpha-alkyl-amino acid derivatives. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.025

文献信息

• Catalytic asymmetric synthesis of cyclic α-alkyl-amino acid derivatives by C,N-double alkylation
  作者：Taichi Kano、Ryu Sakamoto、Haruka Mii、Yong-Gang Wang、Keiji Maruoka

  DOI：10.1016/j.tet.2010.01.105

  日期：2010.6

  Catalytic asymmetric synthesis of various cyclic alpha-alkyl-amino acid derivatives having a tetrasubstituted alpha-carbon, such as alpha-alkylprolines has been accomplished by asymmetric phase-transfer C-alkylation of alpha-alkyl-amino acid derivatives and subsequent intramolecular N-alkylation. (C) 2010 Elsevier Ltd. All rights reserved.