| 1426436-02-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1426436-02-3
• 化学式: C₂₄H₂₁ClN₂O₄S
• 分子量: 468.961
• InChiKey: MYHMZCPCTGHXNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.43
• 重原子数：
  32.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  84.83
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  生成
  参考文献：
  名称：

  The First I2-Promoted Efficient Aminoacetylation of Activated Aziridines in Ionic Liquid

  摘要：

  A novel and efficient aminoacetylation of aziridines is reported. Herein, 2-phenyl-1,3-oxazolan-5-one with tosylaziridines affords 3-(N-substituted)aminopyrrolidin-2-ones via regioselective terminal aziridine opening-aminoacetylative cyclization cascades. The reaction is performed using [bmim]OH/molecular iodine as a new catalyst system where ionic liquid [bmim] OH also works as reaction media and proceeds via an isolable intermediate. After isolation of the product, the ionic liquid, [bmim]OH can be easily recycled for further use without any loss of efficiency. No byproduct formation, operational simplicity, ambient temperature, high yield, and excellent diastereoselectivity are salient features of the present synthetic protocol.

  DOI：

  10.1055/s-0032-1317675
• 作为产物：
  描述：

  2-苯基-5-噁唑酮 、 N-(p-toluenesulfonyl)-2-(4-chlorophenyl)aziridine 在 1-butyl-3-methylimidazolium hydroxide 、 碘 作用下， 反应 2.0h， 生成
  参考文献：
  名称：

  The First I2-Promoted Efficient Aminoacetylation of Activated Aziridines in Ionic Liquid

  摘要：

  A novel and efficient aminoacetylation of aziridines is reported. Herein, 2-phenyl-1,3-oxazolan-5-one with tosylaziridines affords 3-(N-substituted)aminopyrrolidin-2-ones via regioselective terminal aziridine opening-aminoacetylative cyclization cascades. The reaction is performed using [bmim]OH/molecular iodine as a new catalyst system where ionic liquid [bmim] OH also works as reaction media and proceeds via an isolable intermediate. After isolation of the product, the ionic liquid, [bmim]OH can be easily recycled for further use without any loss of efficiency. No byproduct formation, operational simplicity, ambient temperature, high yield, and excellent diastereoselectivity are salient features of the present synthetic protocol.

  DOI：

  10.1055/s-0032-1317675