3-{5H-pyrido[4,3-b]indol-7-yl}propanoicacid | 1892461-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-{5H-pyrido[4,3-b]indol-7-yl}propanoicacid
• 英文别名: 3-(5H-pyrido[4,3-b]indol-7-yl)propanoic acid
• CAS: 1892461-96-9
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.26
• InChiKey: FFZYKDATHLINEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOUNDS FOR TAU PROTEIN DEGRADATION
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20210154184A1

  公开（公告）日：2021-05-27

  Provided herein are bifunctional compounds that bind tau protein and/or promote targeted ubiquitination for the degradation of tau protein. In particular, provided are compounds that can bind tau protein, a protein whose aggregation is implicated in a variety of neurodegenerative disease (e.g., tauopathies), and can promote its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon), which can ubiquitinate tau protein, marking it for proteasomal degradation. Also provided are radiolabeled forms of the bifunctional compounds, pharmaceutical compositions comprising the bifunctional compounds, methods of detecting and/or diagnosing neurological disorders, methods of detecting and/or diagnosing pathological aggregation of tau protein (e.g., in the central nervous system), methods of treating and/or preventing neurological disorders, and methods of promoting the degradation of tau protein by E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.