4-([1,1'-biphenyl]-4-ylcarboxamido)benzoic acid | 270914-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-([1,1'-biphenyl]-4-ylcarboxamido)benzoic acid
• 英文别名: 4-[(biphenyl-4-carbonyl)amino]benzoic acid；4-(4-biphenylylcarbonylamino)benzoic acid；4-[(4-phenylbenzoyl)amino]benzoic acid
• CAS: 270914-11-9
• 化学式: C₂₀H₁₅NO₃
• 分子量: 317.344
• InChiKey: UILPNUDHADCSRK-UHFFFAOYSA-N

物化性质

• 沸点：
  467.7±38.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-([1,1'-biphenyl]-4-ylcarboxamido)benzoic acid 在 lithium hydroxide monohydrate 作用下， 以 水 为溶剂， 以90%的产率得到4-[(biphenyl-4-carbonyl)amino]benzoic acid lithium salt
  参考文献：
  名称：

  Thermoplastic polymer composition

  摘要：

  这项发明提供了符合化学式（C）结构的化合物。 该发明还提供了一种热塑性聚合物组合物，包括聚烯烃聚合物和作为成核剂的符合化学式（C）结构的化合物。

  公开号：

  US09200142B2
• 作为产物：
  描述：

  4-氨基苯甲酸甲酯 在 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 36.0h， 生成 4-([1,1'-biphenyl]-4-ylcarboxamido)benzoic acid
  参考文献：
  名称：

  Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

  摘要：

  Targeting PqsD is a promising novel approach to disrupt bacterial cell-to-cell-communication in Pseudomonas aeruginosa. In search of selective PqsD inhibitors, two series of benzamidobenzoic acids - one published as RNAP inhibitors and the other as PqsD inhibitors - were investigated for inhibitory activity toward the respective other enzyme. Additionally, novel derivatives were synthesized and biologically evaluated. By this means, the structural features needed for benzamidobenzoic acids to be potent and, most notably, selective PqsD inhibitors were identified. The most interesting compound of this study was the 3-Cl substituted compound 5 which strongly inhibits PqsD (IC50 6.2 mu M) while exhibiting no inhibition of RNAP. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.02.014

文献信息

• [EN] THERMOPLASTIC POLYMER COMPOSITION<br/>[FR] COMPOSITION DE POLYMÈRE THERMOPLASTIQUE
  申请人：MILLIKEN & CO

  公开号：WO2015042561A1

  公开（公告）日：2015-03-26

  The invention provides a thermoplastic polymer composition comprising a polyolefin polymer and a nucleating agent. The nucleating agent comprises a compound conforming to the structure of Formula (I). The invention also provides a series of compounds encompassed by the structure of Formula (I).

  这项发明提供了一种热塑性聚合物组合物，包括聚烯烃聚合物和成核剂。该成核剂包括符合式(I)结构的化合物。该发明还提供了一系列符合式(I)结构的化合物。
• Melanin concentrating hormone antagonist
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US07115750B1

  公开（公告）日：2006-10-03

  A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.

  一种黑色素浓缩激素拮抗剂，包括以下式的化合物： 其中Ar1是可能具有取代基团的环状基团； X是具有1到6个原子的主链的间隔物； Y是键或具有1到6个原子的主链的间隔物； Ar是可能与4到8个成员的非芳香环融合的单环芳香环，并且可能具有进一步的取代基团； R1和R2分别是氢原子或可能具有取代基团的碳氢基团；R1和R2，连同相邻的氮原子，可能形成可能具有取代基团的含氮杂环；R2可能与Ar一起形成螺环；或者R2，连同相邻的氮原子和Y，可能形成可能具有取代基团的含氮杂环；或其盐； 该化合物可用作预防或治疗肥胖等疾病的药剂。
• &bgr;-amyloid protein production/secretion inhibitors
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US06586475B1

  公开（公告）日：2003-07-01

  A compound of the formula: wherein Ar is an aromatic group; X and Y are a bivalent group selected from —O—, —S—, —CO—, —SO2—, —NR8—, —CONR8—, SO2NR8 and —COO— (wherein R8 is H, a hydrocarbon group or acyl), or a bivalent C1-6 aliphatic hydrocarbon group which may contain one or two above bivalent groups; R1 and R2 are H or C1-6 alkyl, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring; and ring A is a monocyclic aromatic ring, or a salt thereof or a prodrug thereof exhibits an excellent inhibitory activity of the production and/or the secretion of amyloid-&bgr; protein.

  该化合物的结构式为：其中 Ar 是芳香族基团；X 和 Y 是从—O—、—S—、—CO—、—SO2—、—NR8—、—CONR8—、SO2NR8 和—COO—（其中 R8 是 H、一个碳氢基团或酰基）中选择的双价基团，或者是一个可能含有一个或两个上述双价基团的双价 C1-6 脂肪烃基团；R1 和 R2 是 H 或 C1-6 烷基，或者 R1 和 R2 可以与相邻的氮原子一起形成含氮杂环环；环 A 是单环芳香环，或其盐或前药，表现出对淀粉样蛋白β的产生和/或分泌具有出色的抑制活性。
• THERMOPLASTIC POLYMER COMPOSITION
  申请人：MILLIKEN & COMPANY

  公开号：US20150087759A1

  公开（公告）日：2015-03-26

  The invention provides a compound conforming to the structure of Formula (CXX) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CXX) as a nucleating agent.

  本发明提供了符合CXX式结构的化合物。本发明还提供了一种热塑性聚合物组合物，包括聚烯烃聚合物和符合CXX式结构的化合物作为成核剂。
• BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1132376A1

  公开（公告）日：2001-09-12

  A compound of the formula: wherein Ar is an aromatic group; X and Y are a bivalent group selected from -O-, -S-, -CO-, -SO-, -SO2-, -NR8-,-CONR8-, SO2NR8 and -COO- (wherein R8 is H, a hydrocarbon group or acyl), or a bivalent C1-6 aliphatic hydrocarbon group which may contain one or two above bivalent groups; R1 and R2 are H or C1-6 alkyl, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring; and ring A is a monocyclic aromatic ring, or a salt thereof or a prodrug thereof exhibits an excellent inhibitory activity of the production and/or the secretion of amyloid-β protein.

  式中的化合物： 其中 Ar 是芳香基；X 和 Y 是选自-O-、-S-、-CO-、-SO-、-SO2-、-NR8-、-CONR8-、SO2NR8 和-COO-（其中 R8 是 H、烃基或酰基）的二价基团，或可包含一个或两个上述二价基团的二价 C1-6 脂肪族烃基； R1和R2为H或C1-6烷基，或R1和R2可与相邻的氮原子一起形成含氮杂环；以及环A为单环芳香环，或其盐或其原药对淀粉样β蛋白的产生和/或分泌具有极佳的抑制活性。