N-Fmoc-D-Pmp | 229180-65-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Fmoc-D-Pmp
• 英文别名: (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-(phosphonomethyl)phenyl]propanoic acid
• CAS: 229180-65-8
• 化学式: C₂₅H₂₄NO₇P
• 分子量: 481.442
• InChiKey: OBRYXGOVBZKHLL-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-Ac-D-Phe(p-CH2Cl).OEt 在 盐酸 、 碳酸氢钠 作用下， 以 水 、 丙酮 为溶剂， 反应 21.0h， 生成 N-Fmoc-D-Pmp
  参考文献：
  名称：

  An Efficient Synthesis of N^α-Fmocm-(phosphonomethyl)-L- and D-Phenylalanine

  摘要：

  DOI：

  10.1080/00397919908086231

文献信息

• BIOPROBES AND METHODS OF USE THEREOF
  申请人：The Governing Council of the University of Toronto

  公开号：EP3369828A1

  公开（公告）日：2018-09-05

  Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.

  本发明公开了基于生物大分子的生物探针，这些探针具有更好的水溶性和单层形成特性，而且几乎没有或完全没有聚集，不会明显干扰生物探针与目标核苷酸的结合。生物探针可与合适的报告系统结合使用，以检测极少量的生物标记物。生物探针包括能够与目标核苷酸杂交的核碱基序列；以及至少一个连接到所述核碱基序列上的带电官能团。还公开了生物传感器以及包含生物探针的传感装置。还公开了与生物探针一起使用的合适的电化学报告系统。还包括这些装置和探针的使用方法，包括用于检测目标生物标记物，包括癌细胞或病原体的生物标记物。
• US9335289B2
  申请人：——

  公开号：US9335289B2

  公开（公告）日：2016-05-10
• US9816129B2
  申请人：——

  公开号：US9816129B2

  公开（公告）日：2017-11-14
• [EN] BIOPROBES AND METHODS OF USE THEREOF<br/>[FR] BIOSONDES ET PROCÉDÉS D'UTILISATION DE CELLES-CI
  申请人：UNIV TORONTO

  公开号：WO2012109157A2

  公开（公告）日：2012-08-16

  Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.
• An Efficient Synthesis of N^α-Fmocm-(phosphonomethyl)-L- and D-Phenylalanine
  作者：Liu Bo、Zhan Jiarong

  DOI：10.1080/00397919908086231

  日期：1999.7