2-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethyl)-piperidine | 302969-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethyl)-piperidine
• CAS: 302969-12-6
• 化学式: C₂₀H₂₃NO₃
• 分子量: 325.408
• InChiKey: QOIKUNWNMUTIIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  39.72
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethyl)-piperidine 在 三乙胺 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin

  摘要：

  The benzoindolizidine and-quinolizidine analogues of alpha- and beta-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00130-9
• 作为产物：
  描述：

  1-tert-butoxycarboxy-2-diphenylphosphinylpiperidine 在 sodium tetrahydroborate 、 正丁基锂 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 2-(4-Benzyloxy-benzo[1,3]dioxol-5-ylmethyl)-piperidine
  参考文献：
  名称：

  First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin

  摘要：

  The benzoindolizidine and-quinolizidine analogues of alpha- and beta-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00130-9