N-Acetyl-Tyr-Phe-O-methylester | 19898-34-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-Tyr-Phe-O-methylester
• 英文别名: AC-Tyr-Phe-OMe；methyl (2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoate
• CAS: 19898-34-1
• 化学式: C₂₁H₂₄N₂O₅
• 分子量: 384.432
• InChiKey: FMKAXMXOQRFJPK-OALUTQOASA-N

物化性质

• 沸点：
  692.1±55.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 水 、 叔丁醇 作用下， 生成 N-Acetyl-Tyr-Phe-O-methylester
  参考文献：
  名称：

  Radiolytic one-electron reduction characteristics of tyrosine derivative caged by 2-oxopropyl group

  摘要：

  We employed X-irradiation to activate a caged amino acid with a 2-oxoalkyl group. We designed and synthesized tyrosine derivative caged by a 2-oxoalkyl group (Tyr(Oxo)) to evaluate its radiolytic one-electron reduction characteristics in aqueous solution. Upon hypoxic X-irradiation, Tyr(Oxo) released a 2-oxopropyl group to form the corresponding uncaged tyrosine. In addition, radiolysis of dipeptides containing Tyr(Oxo) revealed that the efficiency of radiolytic removal of 2-oxopropyl group increased significantly by the presence of neighboring aromatic amino acids. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.018

文献信息

• Radiolytic one-electron reduction characteristics of tyrosine derivative caged by 2-oxopropyl group
  作者：Kazuhito Tanabe、Masahiko Ebihara、Nao Hirata、Sei-ichi Nishimoto

  DOI：10.1016/j.bmcl.2008.10.018

  日期：2008.12

  We employed X-irradiation to activate a caged amino acid with a 2-oxoalkyl group. We designed and synthesized tyrosine derivative caged by a 2-oxoalkyl group (Tyr(Oxo)) to evaluate its radiolytic one-electron reduction characteristics in aqueous solution. Upon hypoxic X-irradiation, Tyr(Oxo) released a 2-oxopropyl group to form the corresponding uncaged tyrosine. In addition, radiolysis of dipeptides containing Tyr(Oxo) revealed that the efficiency of radiolytic removal of 2-oxopropyl group increased significantly by the presence of neighboring aromatic amino acids. (C) 2008 Elsevier Ltd. All rights reserved.