Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-α production inhibitor than thalidomide.
少量和双羟基化的
沙利度胺代谢物被高效制备和表征,并评估了它们对人单核细胞白血病
细胞系 THP-1 中肿瘤坏死因子 (TNF)-α 生产的抑制活性。5,N-二羟基
沙利度胺是一种比
沙利度胺更强效的 TNF-α 生产
抑制剂。