4-deoxy-D-xylo-hexose | 5658-14-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-deoxy-D-xylo-hexose
• 英文别名: (2R,3S,5R)-2,3,5,6-tetrahydroxyhexanal
• CAS: 5658-14-0；7286-46-6；30414-17-6；74164-24-2；124338-67-6
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: FRJOXJBNQDZEBI-SRQIZXRXSA-N

物化性质

• 沸点：
  442.7±38.0 °C(Predicted)
• 密度：
  1.414±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-deoxy-D-xylo-hexose 在 sodium tetrahydroborate 作用下， 以75%的产率得到3-Deoxy-L-xylo-hexitol
  参考文献：
  名称：

  Acid-catalysed monoacetalation of two 3-deoxyhexitols

  摘要：

  DOI：

  10.1016/0008-6215(80)90004-x
• 作为产物：
  描述：

  methyl 2,3,6-tri-O-benzoyl-4-deoxy-α-D-xylo-hexopyranoside 在 sodium methylate 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 4-deoxy-D-xylo-hexose
  参考文献：
  名称：

  Acid-catalysed monoacetalation of two 3-deoxyhexitols

  摘要：

  DOI：

  10.1016/0008-6215(80)90004-x

文献信息

• SUGAR KINASES WITH EXPANDED SUBSTRATE SPECIFICITY AND THEIR USE
  申请人：THORSON S. Jon

  公开号：US20050208633A1

  公开（公告）日：2005-09-22

  One preferred embodiment of the present invention provides a GalK variant comprising a Y371H, M173L or Y371H-M173L mutation for in vivo and in vitro glycorandomization. In another preferred embodiment, the E. coli GalK variant is mutated at one or more amino acids including R28, E34, D37, D174, Y233, C339, Y371, Y371H, M173, M173L and C353. The GalK variants display catalytic activity toward a variety of D or L sugars. Another preferred embodiment provides method of phosphorylating sugars comprising the step of incubating a nucleotide triphosphate (NTP) and a D or L sugar in the presence of a GalK variant such that a sugar phosphate is produced. This sugar phosphate may be further incubated with a nucleotidylyltransferase, such that a NDP-sugar is produced. The NDP-sugar may be further incubated with a biomolecule capable of being glycosylated in the presence of a glycosyltransferase, such that a glycosylated biomolecule is produced.
• Sugar Kinases with Expanded Substrate Specificity and Their Use
  申请人：Thorson Jon S.

  公开号：US20090137006A1

  公开（公告）日：2009-05-28

  One preferred embodiment of the present invention provides a GalK variant comprising a Y371H, M173L or Y371H-M173L mutation for in vivo and in vitro glycorandomization. In another preferred embodiment, the E. coli GalK variant is mutated at one or more amino acids including R28, E34, D37, D174, Y223, C339, Y371, Y371H, M173, and M173L. The GalK variants display catalytic activity toward a variety of D or L sugars. Another preferred embodiment provides method of phosphorylating sugars comprising the step of incubating a nucleotide triphosphate (NTP) and a D or L sugar in the presence of a GalK variant such that a sugar phosphate is produced. This sugar phosphate may be further incubated with a nucleotidylyltransferase, such that a NDP-sugar is produced. The NDP-sugar may be further incubated with a biomolecule capable of being glycosylated in the presence of a glycosyltransferase, such that a glycosylated biomolecule is produced.
• US7479385B2
  申请人：——

  公开号：US7479385B2

  公开（公告）日：2009-01-20
• [EN] SUGAR KINASES WITH EXPANDED SUBSTRATE SPECIFICITY AND THEIR USE<br/>[FR] GLYCOKINASES À SPÉCIFICITÉ DE SUBSTRAT ACCRUE, UTILISATION DE CES DERNIÈRES
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2005056786A2

  公开（公告）日：2005-06-23

  One preferred embodiment of the present invention provides a GalK variant comprising a R28, E34, D37, D174, Y233, C339, Y371, Y371H, M173, M173L, Y371H-M173L and C353 mutation. The GalK variants display catalytic activity toward a variety of D or L sugars. Another preferred embodiment provides method of phosphorylating sugars comprising the step of incubating a nucleotide triphosphate (NTP) and a D or L sugar in the presence of a GalK variant such that a sugar phosphate is produced. This sugar phosphate may be further incubated with a nucleotidylyltransferase, such that a NDP-sugar is produced. The NDP-sugar may be further incubated with a biomolecule to produce a glycosylated biomolecule.
• Acid-catalysed monoacetalation of two 3-deoxyhexitols
  作者：Trevor G. Bonner、David Gibson、David Lewis

  DOI：10.1016/0008-6215(80)90004-x

  日期：1980.1