1-Methyl-4-isopropyl-1,2,3,4-tetrahydrochinolin | 59968-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1-Methyl-4-isopropyl-1,2,3,4-tetrahydrochinolin
• 英文别名: 4-isopropyl-1-methyl-1,2,3,4-tetrahydro-quinoline；1-methyl-4-propan-2-yl-3,4-dihydro-2H-quinoline
• CAS: 59968-81-9
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: FDPGTXDKXWGRKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(1-methylquinolin-1-ium-4-yl)propan-2-ol;methyl sulfate 生成 1-Methyl-4-isopropyl-1,2,3,4-tetrahydrochinolin
  参考文献：
  名称：

  FERLES M.; KOCIAN O.; LOEVY J., COLLECT. CZECH. CHEM. COMMUNS , 1976, 41, NO 3, 758-763

  摘要：

  DOI：

文献信息

• Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
  申请人：Array BioPharma Inc.

  公开号：US10351575B2

  公开（公告）日：2019-07-16

  Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

  式 I 的化合物或其立体异构体、同系物或药学上可接受的盐、溶液剂或原药，其中环 A、环 C 和 X 如本文所定义，是 TrkA 激酶的抑制剂，可用于治疗可使用 TrkA 激酶抑制剂治疗的疾病，如疼痛、癌症、炎症/炎症性疾病、神经退行性疾病、某些传染性疾病、Sjogren 综合征、子宫内膜异位症、糖尿病周围神经病变、前列腺炎和盆腔疼痛综合征。
• Inhibitor of apoptosis protein (IAP) antagonists
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US10544188B2

  公开（公告）日：2020-01-28

  Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供了调节细胞凋亡抑制蛋白（IAPs）活性的化合物、包含这些化合物的组合物以及使用这些化合物和包含这些化合物的组合物的方法。
• Inhibitor of Apoptosis Protein (IAP) Antagonists
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US20190135861A1

  公开（公告）日：2019-05-09

  Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
• BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN
  申请人：Array BioPharma Inc.

  公开号：US20190270749A1

  公开（公告）日：2019-09-05

  Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
• US7491827B2
  申请人：——

  公开号：US7491827B2

  公开（公告）日：2009-02-17