1-{4'-[(3R,6S,8R)-3-cyano-6-isobutyl-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yn-8-yl]biphenyl-4-yl}cyclopropanecarboxamide | 1064624-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-{4'-[(3R,6S,8R)-3-cyano-6-isobutyl-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yn-8-yl]biphenyl-4-yl}cyclopropanecarboxamide
• 英文别名: 1-[4-[4-[(3R,6S,8R)-3-cyano-6-(2-methylpropyl)-5-oxo-8-(trifluoromethyl)-1-thia-4,7-diazacycloundec-9-yn-8-yl]phenyl]phenyl]cyclopropane-1-carboxamide
• CAS: 1064624-11-8
• 化学式: C₃₀H₃₁F₃N₄O₂S
• 分子量: 568.663
• InChiKey: JRUHSAOGSLBXOS-AHPZMPFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• CATHEPSIN CYSTEINE PROTEASE INHIBITORS
  申请人：Oballa Renata

  公开号：US20100063013A1

  公开（公告）日：2010-03-11

  The present invention relates to novel compounds of the formula (I), wherein R′-R7, X, Y, D and n are as defined in the specification. These compounds are cysteine protease inhibitors which include but are not limited to inhibitors of cathepsms K, L, S and B and are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

  本发明涉及公式（I）的新化合物，其中R′-R7，X，Y，D和n如规范中所定义。这些化合物是半胱氨酸蛋白酶抑制剂，包括但不限于猫蛋白酶K，L，S和B的抑制剂，并且适用于治疗需要抑制骨吸收的疾病，例如骨质疏松症。
• [EN] CATHEPSIN CYSTEINE PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE CYSTÉINE PROTÉASES DE TYPE CATHEPSINES
  申请人：MERCK FROSST CANADA LTD

  公开号：WO2008116302A1

  公开（公告）日：2008-10-02

  [EN] The present invention relates to novel compounds of the formula (I), wherein R'-R7, X, Y, D and n are as defined in the specification. These compounds are cysteine protease inhibitors which include but are not limited to inhibitors of cathepsms K, L, S and B and are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
  [FR] La présente invention porte sur de nouveaux composés de formule (I), dans laquelle R'-R7, X, Y, D et n sont tels que définis dans la description. Ces composés sont des inhibiteurs de cystéine protéases qui comprennent, mais pas exclusivement, des inhibiteurs des cathepsines K, L, S et B, et sont utiles pour le traitement de maladies, telles que l'ostéoporose, dans lesquelles l'inhibition de la résorption osseuse est indiquée.