N-(2,6-dichloropyridin-4-yl)-2-ethyl-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide | 1352830-00-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: N-(2,6-dichloropyridin-4-yl)-2-ethyl-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide
• 英文别名: 1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)-ethylamino]urea
• CAS: 1352830-00-2
• 化学式: C₁₉H₂₃Cl₂N₇O
• 分子量: 436.344
• InChiKey: CNWFYAGAMGTZRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  88
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] JTE013 ANALOGS AND METHODS OF MAKING AND USING SAME<br/>[FR] ANALOGUES DE JTE013 ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：BRACCO IMAGING SPA

  公开号：WO2011159864A1

  公开（公告）日：2011-12-22

  JTE013 analogs having similar or greater stability relative to JTE013 are provided. Also provided are JTE013 analogs which can bind to both S1P2 and S IP5, some of which also have similar or greater stability relative to JTE013. In addition, methods for the treatment and prevention of diseases and conditions associated with S1P2 and S IP5 receptors are provided.

  提供了与JTE013具有类似或更高稳定性的JTE013类似物。还提供了可以结合到S1P2和S IP5的JTE013类似物，其中一些相对于JTE013也具有类似或更高的稳定性。此外，还提供了与S1P2和S IP5受体相关的疾病和病况的治疗和预防方法。
• S1PR2 antagonists and uses therefor
  申请人：DALHOUSIE UNIVERSITY

  公开号：US10487082B2

  公开（公告）日：2019-11-26

  Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are (Z)-3-((2,6-dichloropyridin-4-yl)amino)-3-(((4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)methyl)amino)acrylonitrile and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.

  本文提供了通过施用治疗有效量的鞘氨醇-1-磷酸受体 2 型（S1PR2）拮抗剂治疗家族性渗出性玻璃体视网膜病变（FEVR）的方法和组合物。本文还提供了(Z)-3-((2,6-二氯吡啶-4-基)氨基)-3-(((4-异丙基-1,3-二甲基-1H-吡唑并[3,4-b]吡啶-6-基)甲基)氨基)丙烯腈及其类似物，以及它们在治疗视网膜病变和以血管生成不足为特征的疾病中的用途。
• S1PR2 ANTAGONISTS AND USES THEREFOR
  申请人：DALHOUSIE UNIVERSITY

  公开号：US20190127372A1

  公开（公告）日：2019-05-02

  Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are compounds which contain bioisosteric replacements of the urea group of JTE-013 and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.
• [EN] S1PR2 ANTAGONISTS AND USES THEREFOR<br/>[FR] ANTAGONISTES DE S1PR2 ET LEURS UTILISATIONS
  申请人：UNIV DALHOUSIE

  公开号：WO2016191872A1

  公开（公告）日：2016-12-08

  Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are compounds which contain bioisosteric replacements of the urea group of JTE- 013 and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.