3-hydroxypropyl 2-phenylpropanoate | 80550-07-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxypropyl 2-phenylpropanoate
• 英文别名: 3-hydoxypropyl-2-phenylpropanoate
• CAS: 80550-07-8
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: ZKDCRSDIMMDJKP-UHFFFAOYSA-N

物化性质

• 沸点：
  281.3±15.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-苯基丙醛 在 sodium hypochlorite 、 硫酸 作用下， 以 溶剂黄146 、 丙酮 为溶剂， 反应 5.25h， 生成 3-hydroxypropyl 2-phenylpropanoate
  参考文献：
  名称：

  Sugai, Saburo; Kodama, Takashi; Akaboshi, Sanya, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 1, p. 99 - 105

  摘要：

  DOI：

文献信息

• 2-Iodoxybenzoic Acid/Tetraethylammonium Bromide/Water: An Efficient Combination for Oxidative Cleavage of Acetals
  作者：Chutima Kuhakarn、Waraporn Panchan、Supanimit Chiampanichayakul、Natthapol Samakkanad、Manat Pohmakotr、Vichai Reutrakul、Thaworn Jaipetch

  DOI：10.1055/s-0028-1087986

  日期：——

  acyclic acetals to the corresponding hydroxyalkyl carboxylic esters and simple esters, respectively. 2-Iodoxybenzoic acid (IBX) in the presence of tetraethylammonium bromide was employed for the reaction in aqueous media. The salient features of the protocol include short reaction time, environmentally benign reagents and solvent, and moderate to high yields. o-iodoxybenzoic acid - acetals - oxidations

  已经开发出一种简单有效的方法，用于将环状和非环状缩醛分别氧化为相应的羟烷基羧酸酯和简单酯。在四乙基溴化铵存在下，将2-碘氧基苯甲酸（IBX）用于水性介质中的反应。该方案的显着特征包括反应时间短，对环境无害的试剂和溶剂以及中等至高产率。 邻碘氧苯甲酸-缩醛-氧化-羟烷基酯-醇
• Facile oxidative hydrolysis of acetals to esters using hypervalent iodine(III)/LiBr combination in water
  作者：Waraporn Panchan、Supanimit Chiampanichayakul、Deanna L. Snyder、Siriporn Yodbuntung、Manat Pohmakotr、Vichai Reutrakul、Thaworn Jaipetch、Chutima Kuhakarn

  DOI：10.1016/j.tet.2010.01.098

  日期：2010.4

  The combination of (diacetoxy)iodobenzene (Phl(OAc)(2), DIB) and lithium bromide (LiBr) efficiently oxidized cyclic and acyclic acetals to the corresponding hydroxyalkyl carboxylic esters and simple esters in good to excellent yields The merits of this reaction are that it employs commercially available and non-explosive hypervalent iodine(III) reagent, water as the solvent, a short reaction tune, and mild reaction conditions (C) 2010 Elsevier Ltd All rights reserved
• Direct Conversion of Aromatic 1,3-Dioxanes to Hydroxypropyl Esters with Pyridinium Hydrobromide Perbromide and Sodium Acetate in Water
  作者：Shinsei Sayama

  DOI：10.3987/com-17-13682

  日期：——

  Various aromatic 1,3-dioxanes were directly converted to respective hydorxypropyl esters with pyridinum hydrobromide perbromide and sodium acetate in water at room temperature.
• SUGAI, SABURO;KODAMA, TAKASHI;AKABOSHI, SANYA;IKEGAMI, SHIRO, CHEM. AND PHARM. BULL., 1984, 32, N 1, 99-105
  作者：SUGAI, SABURO、KODAMA, TAKASHI、AKABOSHI, SANYA、IKEGAMI, SHIRO

  DOI：——

  日期：——