7-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-purin | 15981-64-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物
• 英文名称: 7-(2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl)-purin
• 英文别名: tri-O-acetyl-1-purin-7-yl-β-D-1-deoxy-ribofuranose；7-(2,3,5-Tri-O-acetyl-I(2)-D-ribofuranosyl)-7H-purine；[(2R,3R,4R,5R)-3,4-diacetyloxy-5-purin-7-yloxolan-2-yl]methyl acetate
• CAS: 15981-64-3
• 化学式: C₁₆H₁₈N₄O₇
• 分子量: 378.342
• InChiKey: XABMTVWRIAFFHB-IXYNUQLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.15
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  131.73
• 氢给体数：
  0.0
• 氢受体数：
  11.0

反应信息

• 作为产物：
  描述：

  四乙酰核糖 、 嘌呤 在 牛血清白蛋白 、 三氟甲磺酸三甲基硅酯 作用下， 以 乙腈 为溶剂， 反应 1.08h， 以64.2%的产率得到2',3',5'-tri-O-acetylnebularine
  参考文献：
  名称：

  Microwave-assisted Ribosylation of modified heterocyclic bases by Vorbrüggen method

  摘要：

  During the last decades the nucleoside synthesis has proven to be important. The modified silyl-Hilbert-Johnson nucleoside synthesis modified by Vorbruggen is one of the most often used methods. We have studied N-glycosilation of modifieded heterocyclic bases by Vorbruggen method with microwave irradiation and we were able to shorten the reaction time and obtain higher yields. The method was demonstrated by fluoroquinolone and purine.

  DOI：

  10.1080/15257770701505485