3-(4-hydroxyphenyl)propyl dodecanoate | 1390633-84-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(4-hydroxyphenyl)propyl dodecanoate
• CAS: 1390633-84-7
• 化学式: C₂₁H₃₄O₃
• 分子量: 334.499
• InChiKey: FHGSPNABSISCFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.79
• 重原子数：
  24.0
• 可旋转键数：
  14.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-(4-hydroxyphenyl)propyl dodecanoate 在 2-碘酰基苯甲酸 、 sodium dithionite 作用下， 以 甲醇 、 水 为溶剂， 反应 1.08h， 生成 3-(3,4-dihydroxyphenyl)propyl dodecanoate
  参考文献：
  名称：

  Synthesis and Structure/Antioxidant Activity Relationship of Novel Catecholic Antioxidant Structural Analogues to Hydroxytyrosol and Its Lipophilic Esters

  摘要：

  A large panel of novel catecholic antioxidants and their fatty acid or methyl carbonate esters has been synthesized in satisfactory to good yields through a 2-iodoxybenzoic acid (IBX)-mediated aromatic hydroxylation as the key step. The new catechols are structural analogues of naturally occurring hydroxytyrosol (3,4-DHE). To evaluate structure/activity relationships, the antioxidant properties of all catecholic compounds were evaluated in vitro by ABTS assay and on whole cells by DCF fluorometric assay and compared with that of the corresponding already known hydroxytyrosyl derivatives. Results outline that all of the new catechols show antioxidant capacity in vitro higher than that of the corresponding hydroxytyrosyl derivatives. Less evident positive effects have been detected in whole cells experiments. Cytotoxicity experiments, using MTT assay, on a representative set of compounds evidenced no influence in cell survival.

  DOI：

  10.1021/jf301131a
• 作为产物：
  描述：

  月桂酸乙烯酯 、 3-(4-羟基苯基)-1-丙醇 在 Candida antarctica lipase B in agarose gel droplets Pickering-stabilized by UiO-66/Fe₃O₄ nanoparticles 作用下， 以 丙酮 为溶剂， 反应 12.0h， 生成 3-(4-hydroxyphenyl)propyl dodecanoate
  参考文献：
  名称：

  Magnetic MOF microreactors for recyclable size-selective biocatalysis

  摘要：

  高度多孔的磁性MOF微反应器可以围绕Pickering稳定的水凝胶核心制备，为酶的尺寸选择性生物催化提供了简便的封装手段。

  DOI：

  10.1039/c4sc03367a

文献信息

• Modulation of starch nanoparticle surface characteristics for the facile construction of recyclable Pickering interfacial enzymatic catalysis
  作者：Liang Qi、Zhigang Luo、Xuanxuan Lu

  DOI：10.1039/c9gc00779b

  日期：——

  between the o/w and w/o Pickering interfacial catalytic systems and calculating their mass transfer resistance, we clarified the effects of the location of these two phases on the catalytic capacity of the Pickering emulsion. Impressively, both Pickering interfacial catalytic systems exhibited high effectiveness in product separation. It was found that the w/o Pickering emulsion enabled the organic product

  在这项工作中，玉米淀粉（MS）通过与乙酸酐（AA）和邻苯二甲酸酐（PTA）的酯化反应进行了连续修饰。结合糊化沉淀过程，AA / PTA比为2（MS-AP（2））和3（MS-AP（3））的形成的淀粉纳米颗粒具有相似的规则球体，但表面特征不同。为了增强南极假丝酵母（Candida antarctica（CALB））中的脂肪酶B在有机溶剂中的活性，我们同时设计了水包油（o / w）和油包水（w / o）Pickering界面催化系统通过利用MS-AP（2）和MS-AP（3）作为坚固的Pickering乳化稳定剂。令人印象深刻的是，在1-丁醇和乙酸乙烯酯的酯化过程中，CALB的比活度（o / w（0.0843 UμL -1）或W / O（0.0724ÚμL -1）皮克林界面催化体系比的游离酶更高的单相（0.0198ÚμL -1）和双相（0.0282ûμL -1） 系统。此外，在初步阐述了o / w和w