(E)-4-(3-(4-fluorophenyl)-2-nitroallyl)morpholine | 1211909-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-4-(3-(4-fluorophenyl)-2-nitroallyl)morpholine
• 英文别名: 4-[(E)-3-(4-fluorophenyl)-2-nitroprop-2-enyl]morpholine
• CAS: 1211909-52-2
• 化学式: C₁₃H₁₅FN₂O₃
• 分子量: 266.272
• InChiKey: MCIAOLFACUCAEN-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吗啉 、 聚合甲醛 、 1-(4-氟苯基)-2-硝基乙烯 在 咪唑 、 三氟乙酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 以68%的产率得到(E)-4-(3-(4-fluorophenyl)-2-nitroallyl)morpholine
  参考文献：
  名称：

  One-pot three component α-aminoalkylation of conjugated nitroalkenes and nitrodienes

  摘要：

  Nitroethylenes possessing aryl, heteroaryl, and alkyl substituents at the beta-position as well as delta-substituted nitrobutadienes undergo facile aminoalkylation at the alpha-position upon treatment with formaldehyde and a secondary amine in the presence of imidazole and trifluoroacetic acid to afford alpha-aminoalkylated nitroalkenes and nitrodienes in good to excellent yield and stereoselectivity. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.015

文献信息

• One-pot three component α-aminoalkylation of conjugated nitroalkenes and nitrodienes
  作者：Kunjanpillai Rajesh、Pramod Shanbhag、Manjoji Raghavendra、Pallavi Bhardwaj、Irishi N.N. Namboothiri

  DOI：10.1016/j.tetlet.2009.12.015

  日期：2010.2

  Nitroethylenes possessing aryl, heteroaryl, and alkyl substituents at the beta-position as well as delta-substituted nitrobutadienes undergo facile aminoalkylation at the alpha-position upon treatment with formaldehyde and a secondary amine in the presence of imidazole and trifluoroacetic acid to afford alpha-aminoalkylated nitroalkenes and nitrodienes in good to excellent yield and stereoselectivity. (c) 2009 Elsevier Ltd. All rights reserved.