Pentizidone | 55694-83-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Pentizidone
• 英文别名: (4R)-4-[[(E)-4-oxopent-2-en-2-yl]amino]-1,2-oxazolidin-3-one
• CAS: 55694-83-2
• 化学式: C₈H₁₂N₂O₃
• 分子量: 184.19
• InChiKey: DGYLXKOLHICICX-OHCKJTPYSA-N

物化性质

• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Pentizidone 生成 乙酰丙酮
  参考文献：
  名称：

  FEDOR, L. R., INT. J. PHARM., 1985, 22, N 2-3, 197-205

  摘要：

  DOI：

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Controlled drug device and process for catalysing the erosion of an acid labile polymer
  申请人：Merck & Co., Inc.

  公开号：EP0208617A1

  公开（公告）日：1987-01-14

  The invention relates to the use of carboxylic, sulfonic, phosphatidic and/or phosphate ester acids incorporated as a catalyst in poly(ortho­ester)s and other acid labile polymers such that upon exposure to aqueous environments the acid catalyzes the erosion of the polymer matrix. The rate of release of a drug substance incorporated into or surrounded by the poly(orthoester) or other acid labile polymer can be controlled in that the drug is released as the polymer is eroded in response to the catalytic action of the acid incorporated therein.

  本发明涉及使用羧酸、磺酸、磷脂酸和/或磷酸酯酸作为催化剂加入聚（邻苯二甲酸酯）和其他酸性聚合物中，使其在暴露于水性环境时催化聚合物基质的侵蚀。掺入聚（邻苯二甲酸酯）或其他酸性聚合物中或被其包围的药物物质的释放速度可以得到控制，因为在掺入其中的酸的催化作用下，当聚合物被侵蚀时，药物就会释放出来。
• Pharmaceutical composition of the type which undergoes liquid-gel phase transition
  申请人：LABORATOIRES MERCK, SHARP & DOHME-CHIBRET

  公开号：EP0227494A1

  公开（公告）日：1987-07-01

  The present invention relates to a pharmaceutical composition intended for contacting with a physiological liquid characterized in that said composition is intended to be administered as a non-gelled liquid form and is intended to gel in situ, this composition containing at least one polysaccharide in aqueous solution, of the type which undergoes liquid-gel phase transition gelling in situ under the effect of an increase in the ionic strength of said physiological liquid.

  本发明涉及一种用于与生理液体接触的药物组合物，其特征在于所述组合物以非凝胶液体形式给药，并可在原位凝胶，该组合物含有至少一种水溶液中的多糖，这种多糖在所述生理液体离子强度增加的作用下发生液-凝胶相变，在原位凝胶。
• Novel antibacterial agents and potentiators of carbapenem antibiotics
  申请人：Merck & Co., Inc.

  公开号：EP0266978A2

  公开（公告）日：1988-05-11

  New 3-(1-aminoalkylphosphinyl)-(2-substi­tuted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.

  文中描述了新的 3-(1-氨基烷基膦酰基)-(2-取代)丙酸，它们具有抗菌活性并能增强碳青霉烯类抗生素的作用。
• Solubility modulated drug delivery device
  申请人：Merck & Co., Inc.

  公开号：EP0314206A1

  公开（公告）日：1989-05-03

  The instant invention is directed to a drug-delivery device for the controlled release of a therapeutically active ingredient into an environment of use which comprises: (A) a core composition comprising (a) a solubility modulating agent which is either (i) surrounded by a water insoluble coat containing at least one pore forming additive dispersed throughout said coat, or (ii) dispersed in a matrix substrate, and (b) a diffusible water soluble therapeutically active ingredient; and (B) a water insoluble wall surrounding said core composition and prepared from (i) a polymer material that is permeable to water but substantially impermeable to solute and (ii) 0.1 to 75% by weight, based on the total weight of (i) and (ii), of at least one water leachable pore forming additive dispersed throughout said wall; or (C) a substantially imperforate water insoluble wall surrounding said core composition and prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall.

  本发明涉及一种将治疗活性成分控制释放到使用环境中的给药装置，该装置包括 (A) 核心成分，包括 (a) 溶解度调节剂，其(i)被不溶于水的外衣包围，该外衣至少含有一种分散在所述外衣中的孔形成添加剂，或(ii)分散在基质基材中，以及 (b) 可扩散的水溶性治疗活性成分； 和 (B) 围绕所述核心成分的水不溶壁，由以下材料制备而成 (i) 可渗透水但基本上不渗透溶质的聚合物材料，以及 (ii) 分散在整个所述壁中的至少一种可渗透水的孔隙形成添加剂，按重量计，占(i)和(ii)总重量的 0.1%至 75%；或 (C) 围绕所述核心成分的基本上不穿孔的不溶于水的壁，由基本上不渗透核心成分并可渗透使用环境中的外部流体的半渗透材料制备而成，所述壁具有通过不溶于水的壁释放治疗剂的装置。