(2RS,2'RS)-2'-bromo-3,4-dihydro-spiro[furan-2,1'-indan]-5-one | 108238-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (2RS,2'RS)-2'-bromo-3,4-dihydro-spiro[furan-2,1'-indan]-5-one
• 英文别名: (2RS,2'RS)-2'-bromo-3,4-dihydro-spiro[furan-2,1'-indan]-5-one；(2RS,2'RS)-2'-Brom-3,4-dihydro-spiro[furan-2,1'-indan]-5-on
• CAS: 108238-21-7
• 化学式: C₁₂H₁₁BrO₂
• 分子量: 267.122
• InChiKey: XKUPKQDHKNZYDQ-JQWIXIFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  15.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  茚 在 emulsifier 、 溴 、 sodium methylate 、 sodium bromide 作用下， 生成 (2RS,2'RS)-2'-bromo-3,4-dihydro-spiro[furan-2,1'-indan]-5-one
  参考文献：
  名称：

  February asthma outbreaks in NSW: a case control study

  摘要：

  Objectives: To investigate individual factors associated with an asthma outbreak among children aged one to 14 years in Sydney in February 1999. Methods: A case control study was undertaken with cases (n=92) defined as all children admitted to Sydney Children's Hospital for asthma in February 1999. Unmatched controls (n=76) were all children admitted for asthma in the previous three months. We obtained information by a structured telephone survey of parents. Logistic regression analyses were used to determine odds ratios for risk factors for hospital admission. Results: Mean age for hospital admission of 4.7 years for cases and 4.4 years for controls. The presence of one or more siblings reduced the risk of admission during an asthma outbreak (OR=0.59, 95% Cl 0.37 to 0.93). Children with older siblings aged 10 to 14 years were also less likely to be admitted (OR=0.3, 95% Cl 0.12 to 0.74). An age effect was observed. Other demographic, clinical and environmental characteristics, including smoking, were not associated with admission during the outbreak. Conclusions: The main findings of this study are the protective effect of siblings and an age-dependent effect in risk of hospital admission during an asthma outbreak. These findings are consistent with an infective cause of the outbreak. Implications: Children without siblings, particularly older siblings, appear to be at highest risk of hospital admission during an asthma outbreak. Environmental and other factors need to be examined to further explain the episodicity of such outbreaks and to determine means of predicting and preventing future episodes.

  DOI：

  10.1111/j.1467-842x.2001.tb00315.x

文献信息

• Enantioselective Bromolactonization of Trisubstituted Olefinic Acids Catalyzed by Chiral Pyridyl Phosphoramides
  作者：Yasuhiro Nishikawa、Yuhta Hamamoto、Rika Satoh、Naho Akada、Shuhei Kajita、Marina Nomoto、Megumi Miyata、Madoka Nakamura、Chinatsu Matsubara、Osamu Hara

  DOI：10.1002/chem.201804630

  日期：2018.12.17

  Enantioselective bromolactonization of trisubstituted olefinic acids producing synthetically useful chiral lactones with two contiguous asymmetric centers has remained mainly unexplored except for the 6‐exo cyclization mode. In this work, the 5‐exo‐ and 6‐endo modes of bromocyclization of trisubstituted olefinic acids were enabled for the first time using N‐bromosuccinimide and a pyridyl phosphoramide

  除6- exo环化方式外，三取代烯烃生产具有两个连续不对称中心的合成有用的手性内酯的对映选择性溴内酯化主要仍未开发。在这项工作中，使用N首次启用了三取代烯烃的溴环化的5-外和6-内环模式。-溴代琥珀酰亚胺和吡啶基磷酰胺催化剂。通过利用反应性烷基溴化物部分进行转化而不丧失立体化学信息，证明了所得溴内酯的实用性。优化研究和对照实验表明，磷酰胺物种中吡啶部分的碱性和NH质子的存在强烈影响反应性和对映选择性参数。