6-bromo-1-(4-piperidinyl)-indole | 321745-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-bromo-1-(4-piperidinyl)-indole
• 英文别名: 1-(piperidin-4-yl)-6-bromoindole；6-Bromo-1-piperidin-4-ylindole
• CAS: 321745-23-7
• 化学式: C₁₃H₁₅BrN₂
• 分子量: 279.18
• InChiKey: XKSJOUIFKPJNFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  17
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Indoles
  申请人：Eisai Co., Ltd.

  公开号：US20020019531A1

  公开（公告）日：2002-02-14

  A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: 1 wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R 1 , R 2 , R 3 , R 4 , and R 5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.

  一种由以下公式表示的1,4-取代的环胺衍生物或其药理学上可接受的盐： 其中A、B、C、D、T、Y和Z分别表示亚甲基或氮键合物；R1、R2、R3、R4和R5分别表示取代基；n表示0或1至3的整数；m表示0或1至6的整数；p表示1至3的整数。这些化合物具有5-羟色胺拮抗作用。因此，在临床上作为药物特别有用，用于治疗、改善和预防痉挛性瘫痪。它们还可用作中枢肌肉松弛剂，改善肌张力过高。
• Heterocyclic compounds for the treatment of migraine
  申请人：NPS ALLELIX BIOPHARMACEUTICALS, INC.

  公开号：US20040167158A1

  公开（公告）日：2004-08-26

  Described herein are compounds useful in the treatment of migraine, which have the general formula: 1 wherein: W is a CH group or a N atom; Z is N or C-R4; B and D are selected independently from CH and N, with the proviso that at least one of B and D is CH and with the further proviso that one of B and D can represent N only when W and Z are both other than N; A is a group of Formula II, III or IV, such that group A contains at least 1 N atom; NR7 is either —NH— or —N═ is a single or double bond; X is a N atom, a CH group or a C(OH) group when is a single bond; or, when is a double bond, a C atom; Y is an NH, N-alkyl, N-benzyl or CH 2 group; U and V each represent a N atom or a CH group, with the proviso that both cannot be N; a and b are, independently, 0 or 1; c is an integer from 0 to 3; d is an integer from 1 to 3; e is an integer from 1 to 2; f is an integer from 0 to 3; g is an integer from 3 to 6 and h is an integer from 2 to 3; such that the sum of c and d is at least 2 and the sum of e and f is at least 2; R 1 is selected from the group consisting of H, alkyl, alkyloxy, alkanoyl, aminoalkylenyl, alkylaminoalkylenyl, a hydroxyalkylenyl group, an alkyloxyalkylenyl group, a cycloalkyl group, a cycloalkylalkylenyl group, a heterocycloalkyl group, a heterocycloalkylalkylenyl group, an aryl group, a heterocycloaryl group, an amido group, a thioamido group, an arylcarbonyl group and an arylsulfonyl group; R 2 and R 3 are independently selected from the group consisting of H, alkyl, cycloalkyl, alkenyl and optionally-substituted benzyl; or R 2 and R 3 , together with the nitrogen atom to which they are attached, may form a mono- or bi-cyclic group containing up to 10 carbon atoms and which, in addition, may contain a second heteroatom selected from the group consisting of N, S and O, and which may contain one or more substituents selected from the group consisting of alkyl, hydroxy, hydroxymethyl, alkyloxymethyl, amino and substituted amino; R 4 is selected from the group consisting of H, alkyl and cycloalkyl; CR 5 represents a group selected from —CH2—, CH(OH)—, —C(O)—, —CH(alkyl)- and —CH(alkyloxy)-; R6 is selected from the group consisting of H, alkyl, aryl, halogen, hydroxy, alkyloxy, amino, monoalkylamino and di-substitutedalkylamino; and salts and solvates thereof

  本文描述了治疗偏头痛的化合物，其具有以下通式：1其中：W是CH基团或N原子；Z是N或C-R4；B和D独立地选自CH和N，但至少其中之一为CH，并进一步规定当W和Z都不是N时，B和D中的一个可以表示N；A是公式II、III或IV的基团，使得基团A至少包含1个N原子；NR7是—NH—或—N═；is a single or double bond；当is a double bond时，X是C原子；Y是NH、N-烷基、N-苯甲基或CH2基团；U和V分别表示N原子或CH基团，但两者不能同时为N；a和b独立地为0或1；c是0到3之间的整数；d是1到3之间的整数；e是1到2之间的整数；f是0到3之间的整数；g是3到6之间的整数；h是2到3之间的整数；使得c和d的和至少为2，e和f的和至少为2；R1选自H、烷基、烷氧基、烷酰基、氨基烷基亚烷基、烷基氨基烷基亚烷基、羟基烷基亚烷基、烷氧基烷基亚烷基、环烷基、环烷基烷基亚烷基、杂环烷基、杂环烷基烷基亚烷基、芳基、杂环芳基、酰胺基、硫酰胺基、芳基羰基和芳基磺酰基的群；R2和R3独立地选自H、烷基、环烷基、烯基和可选取代苄基的群；或者R2和R3与它们所连接的氮原子一起，可以形成一个含有最多10个碳原子的单环或双环基团，此外，该基团还可以含有从N、S和O组成的第二个杂原子，以及从烷基、羟基、羟甲基、烷氧甲基、氨基和取代氨基的群中选择的一个或多个取代基；R4选自H、烷基和环烷基；CR5表示选自— —、CH(OH)—、—C(O)—、—CH(烷基)-和—CH(烷氧基)-的基团；R6选自H、烷基、芳基、卤素、羟基、烷氧基、氨基、单烷基氨基和二取代烷基氨基的群；以及其盐和溶剂络合物。
• Certain quinoline derivatives
  申请人：Eisai Co., Ltd.

  公开号：US20020086999A1

  公开（公告）日：2002-07-04

  A novel 1,4-substituted cyclic amine derivative represented by the following formula: 1 wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R 1 , R 2 , R 3 , R 4 , and R 5 represent each a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3; and pharmacologically acceptable salts thereof. The compound has a serotonin antagonism and is clinically useful as medicament, in particular, for treating, ameliorating and preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.

  由下式表示的新型 1,4-取代环胺衍生物： 1 其中 A、B、C、D、T、Y 和 Z 分别代表甲烷或氮； R 1 , R 2 , R 3 , R 4 和 R 5 分别代表一个取代基；n 代表 0 或 1 至 3 的整数；m 代表 0 或 1 至 6 的整数；p 代表 1 至 3 的整数；及其药理上可接受的盐类。该化合物具有血清素拮抗作用，在临床上可用作药物，特别是用于治疗、改善和预防痉挛性瘫痪或用于改善肌张力的中枢性肌肉松弛剂。
• 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES
  申请人：Eisai Co., Ltd.

  公开号：EP0976732B1

  公开（公告）日：2004-11-24
• INDOLES AND INDAZOLES FOR THE TREATMENT OF MIGRAINE
  申请人：NPS Allelix Corp.

  公开号：EP1196380A2

  公开（公告）日：2002-04-17