(Z)-2-(5-((4-chloro-2-(morpholin-4-yl)-1,3-thiazol-5-yl)methylidene)-2,4-dioxothiazolidin-3-yl)acetic acid | 1375004-20-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-2-(5-((4-chloro-2-(morpholin-4-yl)-1,3-thiazol-5-yl)methylidene)-2,4-dioxothiazolidin-3-yl)acetic acid
• CAS: 1375004-20-8
• 化学式: C₁₃H₁₂ClN₃O₅S₂
• 分子量: 389.84
• InChiKey: JAFBPSCYESDPDW-YVMONPNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  100.04
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  (Z)-ethyl 2-(5-((4-chloro-2-(morpholin-4-yl)-1,3-thiazol-5-yl)methylidene)-2,4-dioxothiazolidin-3-yl)acetate 在 盐酸 、 溶剂黄146 作用下， 反应 4.0h， 以74%的产率得到(Z)-2-(5-((4-chloro-2-(morpholin-4-yl)-1,3-thiazol-5-yl)methylidene)-2,4-dioxothiazolidin-3-yl)acetic acid
  参考文献：
  名称：

  Synthesis and antidiabetic activity of morpholinothiazolyl-2,4-thiazolidindione derivatives

  摘要：

  We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 11-15 (at lower concentration; 0.001 mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and extrapancreatic effects.

  DOI：

  10.3109/14756366.2011.594047