| 1331822-85-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1331822-85-5
• 化学式: C₈H₁₅N₄O₈P
• 分子量: 326.203
• InChiKey: KYVZMJWFPJXDMX-RZUNNTJFSA-N

反应信息

• 作为产物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of 4-Azido-N-acetylhexosamine Uridine Diphosphate Donors: Clickable Glycosaminoglycans

  摘要：

  Unnatural chemically modified nucleotide sugars UDP-4-N-3-GlcNAc and UDP-4-N-3-GalNAc were chemically synthesized for the first time. These unnatural UDP sugar products were then tested for incorporation into hyaluronan, heparosan, or chondroitin using polysaccharide synthases. UDP-4-N-3-GlcNAc served as a chain termination substrate for hyaluronan or heparosan synthases; the resulting 4-N-3-GlcNAc-terminated hyaluronan and heparosan were then successfully conjugated with Alexa Fluor 488 DIBO alkyne, demonstrating that this approach is generally applicable for labeling and detection of suitable glycosaminoglycans.

  DOI：

  10.1021/acs.joc.7b01787