3-Methyl-3-methoxy-cyclobutan-carbonsaeure-methylester | 5119-74-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Methyl-3-methoxy-cyclobutan-carbonsaeure-methylester
• 英文别名: Methyl 3-methoxy-3-methylcyclobutane-1-carboxylate
• CAS: 5119-74-4
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: NTHMIVOJURJKBM-UHFFFAOYSA-N

物化性质

• 沸点：
  173.3±33.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Methyl-3-methoxy-cyclobutan-carbonsaeure-methylester 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 以80.0 %的产率得到3-methoxy-3-methylyclobutanecarboxylic acid
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS OF MAKING AND USING SMALL MOLECULES IN THE TREATMENT OF CANCER
  [FR] COMPOSITIONS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE PETITES MOLÉCULES DANS LE TRAITEMENT DU CANCER

  摘要：

  Embodiments of the instant disclosure relate to novel compounds, compositions, and methods for treating health conditions. In certain embodiments, methods of treating cancers can include administering an effective amount of at least one novel compound disclosed herein to a subject having cancer. In some embodiments, methods of treating cancers can include administering a pharmaceutical composition disclosed herein to a subject, the composition including at least one of the novel compounds disclosed herein, and optionally, one additional agent.

  公开号：

  WO2023111996A1
• 作为产物：
  描述：

  3-氧代环丁烷甲酸甲酯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 16.67h， 生成 3-Methyl-3-methoxy-cyclobutan-carbonsaeure-methylester
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS OF MAKING AND USING SMALL MOLECULES IN THE TREATMENT OF CANCER
  [FR] COMPOSITIONS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE PETITES MOLÉCULES DANS LE TRAITEMENT DU CANCER

  摘要：

  Embodiments of the instant disclosure relate to novel compounds, compositions, and methods for treating health conditions. In certain embodiments, methods of treating cancers can include administering an effective amount of at least one novel compound disclosed herein to a subject having cancer. In some embodiments, methods of treating cancers can include administering a pharmaceutical composition disclosed herein to a subject, the composition including at least one of the novel compounds disclosed herein, and optionally, one additional agent.

  公开号：

  WO2023111996A1

文献信息

• Bicyclo[1.1.0]butane
  作者：K.B. Wiberg、G.M. Lampman、R.P. Ciula、D.S. Connor、P. Schertler、J. Lavanish

  DOI：10.1016/s0040-4020(01)98361-9

  日期：1965.1

  The chemistry of bicyclo[1.1.0]butane and some of its derivatives is reviewed. The effect of its bond angle deformation on its strain energy, its orbital hybridization, and its reactivity is discussed.

  综述了双环[1.1.0]丁烷及其某些衍生物的化学性质。讨论了键角变形对其应变能，轨道杂交及其反应性的影响。
• RAZIN, V. V.;EREMENKO, M. V.;CHERNITSYNA, O. A., ZH. ORGAN. XIMII, 25,(1989) N1, S. 2305-2312
  作者：RAZIN, V. V.、EREMENKO, M. V.、CHERNITSYNA, O. A.

  DOI：——

  日期：——
• US20140343019A1
  申请人：——

  公开号：US20140343019A1

  公开（公告）日：2014-11-20