chloroindolenine | 86691-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: chloroindolenine
• 英文别名: 3h-Indole chloride；2-chloro-3H-indole
• CAS: 86691-38-5
• 化学式: C₈H₆ClN
• mdl: MFCD18813542
• 分子量: 151.595
• InChiKey: XPVBKMRHWYGXMY-UHFFFAOYSA-N

物化性质

• 沸点：
  262.1±43.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• LTA4H modulators and uses thereof
  申请人：Barchuk William T.

  公开号：US20080194630A1

  公开（公告）日：2008-08-14

  Leukotriene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation.

  白三烯A4水解酶（LTA4H）抑制剂，含有它们的组合物，以及用于抑制LTA4H酶活性和治疗、预防或抑制炎症和/或与炎症相关疾病的方法。
• HETEROBICYCLIC COMPOUNDS
  申请人：Amgen Inc.

  公开号：US20130225552A1

  公开（公告）日：2013-08-29

  Heterobicyclic compounds of Formula (I): or a pharmaceutically-acceptable salt, tautomer, or stereoisomer thereof, as defined in the specification, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's Disease, and the like.

  Formula (I)的杂环化合物： 或其药用可接受的盐、互变异构体或立体异构体，如规范中所定义，并含有它们的组合物，以及制备这种化合物的方法。本文还提供了通过抑制PDE10来治疗由此可治疗的疾病或疾病的方法，如肥胖症、非胰岛素依赖型糖尿病、精神分裂症、躁郁症、强迫症、亨廷顿病等。
• DEVICE AND PROCESS FOR CONTINUOUS PHOSGENATION
  申请人：Pilia Raimondo

  公开号：US20130303783A1

  公开（公告）日：2013-11-14

  A continuous process for generation of phosgene from CO and Cl 2 and consumption of the phosgene thus generated in a liquid-phase reaction so as to form organic products P. The process is implemented in two successive reactors R1 and R2, the first reactor R1 being a reactor for catalytic synthesis of phosgene from CO and Cl2 gas, and the second reactor R2 being a piston reactor, the second reactor R2 being equipped with a mechanical axial agitation device.

  从CO和Cl2生成光气，并将生成的光气在液相反应中消耗以形成有机产品P的连续过程。该过程在两个连续反应器R1和R2中实施，第一个反应器R1是用于从CO和Cl2气体催化合成光气的反应器，第二个反应器R2是一个活塞反应器，第二个反应器R2配备有机械轴向搅拌装置。
• BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
  申请人：Sandanayaka Vincent

  公开号：US20070066820A1

  公开（公告）日：2007-03-22

  The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

  这项发明涉及一种化学类别的双芳基取代杂环抑制剂，用于治疗、预防和预防炎症性疾病和紊乱。这些化合物具有一般公式Ψ：一个例子是
• [EN] BICYCLIC FUSED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF RSV<br/>[FR] DÉRIVÉS PYRAZOLE CONDENSÉS BICYCLIQUES POUR LE TRAITEMENT DE RSV
  申请人：UNIV GEORGIA STATE RES FOUND

  公开号：WO2017196982A1

  公开（公告）日：2017-11-16

  Disclosed herein are compounds and compositions for treating or inhibiting RSV and related members of the pneumovirus and paramyxovirus families such as human metapneumovirus, mumps virus, human parainfluenzaviruses, and Nipah and hendra virus, and methods of treatment or prevention thereof.

  本公开涉及用于治疗或抑制RSV及其相关的肺炎病毒和副粘病毒家族成员，如人类副流感病毒、腮腺病毒、人类副流感病毒和尼帕病毒和亨德拉病毒的化合物和组合物，以及其治疗或预防方法。