N-[1(R)-[(2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperdin]-1'-yl)carbonyl]-4-phenylbutyl]-2-[(1,1-dimethylethoxy)carbonyl]amino-2-methylpropanamide | 185526-08-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[1(R)-[(2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperdin]-1'-yl)carbonyl]-4-phenylbutyl]-2-[(1,1-dimethylethoxy)carbonyl]amino-2-methylpropanamide
• 英文别名: tert-butyl N-[2-methyl-1-oxo-1-[[(2R)-1-oxo-1-(3-oxospiro[2H-indene-1,4'-piperidine]-1'-yl)-5-phenylpentan-2-yl]amino]propan-2-yl]carbamate
• CAS: 185526-08-3
• 化学式: C₃₃H₄₃N₃O₅
• 分子量: 561.722
• InChiKey: YFYNBQYJCGKXAW-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-[1(R)-[(2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperdin]-1'-yl)carbonyl]-4-phenylbutyl]-2-[(1,1-dimethylethoxy)carbonyl]amino-2-methylpropanamide 在 盐酸 、 sodium tetrahydroborate 作用下， 生成 2-amino-N-[(2R)-1-(1-hydroxyspiro[1,2-dihydroindene-3,4'-piperidine]-1'-yl)-1-oxo-5-phenylpentan-2-yl]-2-methylpropanamide;hydrochloride
  参考文献：
  名称：

  The synthesis and activity of spiroindane growth hormone secretagogues

  摘要：

  The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00075-9
• 作为产物：
  描述：

  在 N-甲基吗啉 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 N-[1(R)-[(2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperdin]-1'-yl)carbonyl]-4-phenylbutyl]-2-[(1,1-dimethylethoxy)carbonyl]amino-2-methylpropanamide
  参考文献：
  名称：

  The synthesis and activity of spiroindane growth hormone secretagogues

  摘要：

  The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00075-9

文献信息

• Spiro piperidines and homologs promote release of growth hormone
  申请人：Merck & Co., Inc.

  公开号：US05578593A1

  公开（公告）日：1996-11-26

  There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.

  本发明揭示了一些新型化合物，它们被识别为螺环吡啶和同系物，可以促进人类和动物体内生长激素的释放。这种特性可以用于促进食用动物的生长，从而使可食用肉类产品的生产更加高效，同时也可以用于治疗生长激素分泌缺乏的生理或医学状况，如生长激素缺乏症儿童的矮小症，以及通过生长激素的合成作用改善的医学状况。本发明还揭示了含有这些螺环化合物作为活性成分的生长激素释放组合物。
• US5578593A
  申请人：——

  公开号：US5578593A

  公开（公告）日：1996-11-26